New project optimising photochemical internalisation to avoid neuronal toxicity

Photochemical Internalisation (PCI) is a novel drug delivery technology founded upon Photodynamic Therapy (PDT). In PCI, low dose PDT can selectively rupture endo/lysosomal membranes by light activation of membrane-incorporated photosensitisers, facilitating intracellular drug release. PCI is currently being tested in patients at UCLH with advanced head and neck cancer (HNC) undergoing Bleomycin chemotherapy (more information). […]