Publications

Some of our recent publications are listed below. To find more please visit UCL IRIS

 

Latest Papers

Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing

Added 3 March, 2024

RP Trueman, O Guillemot-Legris, HT Lancashire, AS Mehta, J Tropp, RE Daso, J Rivnay, AB Tabor, JB Phillips & BC Schroeder (2024). Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing. Advanced Engineering Materials, e2301488. 10.1002/adem.202301488.

Electrospun polyvinylidene fluoride with novel facile synthesized functionalized boron nitride quantum dots for neural applications

Added 3 March, 2024

B Ekram, RP Trueman, JB Phillips, H Ros, BM Abd El-Hady, D El-Gendy (2024) Electrospun polyvinylidene fluoride with novel facile synthesized functionalized boron nitride quantum dots for neural applications. Polymer Engineering and Science 10.1002/pen.26632.

Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair

Added 12 October, 2023

HN Gregory, O Guillemot-Legris, D Crouch, G Williams & JB Phillips (2023) Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair. Regenerative Medicine https://doi.org/10.2217/rme-2023-0151

Development of ibuprofen-loaded electrospun materials suitable for surgical implantation in peripheral nerve injury

Added 12 October, 2023

K Dziemidowicz, SC Kellaway, O Guillemot-Legris, O Matar, R Pereira Trindade, VH Roberton, MLD Rayner, GR Williams & JB Phillips (2023) Development of ibuprofen-loaded electrospun materials suitable for surgical implantation in peripheral nerve injury. Biomaterials Advances 154, 213623, https://doi.org/10.1016/j.bioadv.2023.213623

Mathematical modelling with Bayesian inference to quantitatively characterize therapeutic cell behaviour in nerve tissue engineering

Added 12 October, 2023

M Berg, D Eleftheriadou, JB Phillips & RJ Shipley (2023) Mathematical modelling with Bayesian inference to quantitatively characterize therapeutic cell behaviour in nerve tissue engineering. Journal of the Royal Society Interface, 20 (206), 20230258.  10.1098/rsif.2023.0258.

Local Administration of Minocycline Improves Nerve Regeneration in Two Rat Nerve Injury Models

Added 30 July, 2023

O Guillemot-Legris, G Girmahun, RJ Shipley & JB Phillips (2023). Local Administration of Minocycline Improves Nerve Regeneration in Two Rat Nerve Injury Models. Int J Mol Sci 24, 12085

Serum neurofilament light chain measurements following nerve trauma

Added 30 July, 2023

M Wilcox, MLD Rayner, O Guillemot-Legris, I Platt, H Brown, T Quick & JB Phillips (2023). Serum neurofilament light chain measurements following nerve trauma. J Peripher Nerv Syst. https://doi.org/10.1111/jns.12576

Improving the biological interfacing capability of diketopyrrolopyrrole polymers via p-type doping

Added 30 July, 2023

RP Trueman, PG Finn, MM Westwood, A Dey, R Palgrave, A Tabor, JB Phillips & BC Schroeder (2023). Improving the biological interfacing capability of diketopyrrolopyrrole polymers via p-type doping. J Mater Chem C Mater 11, 6943-6950

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

Added 28 May, 2023

G Gong, B Bilanges, B Allsop, GR Masson, V Roberton, T Askwith, S Oxenford, RR Madsen, SE Conduit, D Bellini, M Fitzek, M Collier, O Najam, Z He, B Wahab, SH McLaughlin, AWE Chan, I Feierberg, A Madin, D Morelli, A Bhamra, V Vinciauskaite, KE Anderson, S Surinova, N Pinotsis, E Lopez-Guadamillas, M Wilcox, A Hooper, C Patel, MA Whitehead, TD Bunney, LR Stephens, PT Hawkins, M Katan, DM Yellon, SM Davidson, DM Smith, JB Phillips, R Angell, RL Williams & B Vanhaesebroeck (2023). A small-molecule PI3Kα activator for cardioprotection and neuroregeneration. Nature https://doi.org/10.1038/s41586-023-05972-2

Exploring the Effect of Vitamins B1, B6 and B12 on Neurite Regeneration using a 3D Co-Culture Model of Neurodegeneration

Added 19 May, 2023

PO Smith, RP Trueman, R Powell, H Gregory, JB Phillips, P Bohnhorst & MLD Rayner (2023). Exploring the Effect of Vitamins B1, B6 and B12 on Neurite Regeneration using a 3D Co-Culture Model of Neurodegeneration. International Journal of Physical Medicine & Rehabilitation 11, 1000667

Culture Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-Centre Study

Added 18 March, 2023

Z Huang, R Powell, S Kankowski, JB Phillips & K Haastert-Talini (2023). Culture Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-Centre Study. International Journal of Molecular Sciences 24(6), 5366. https://doi.org/10.3390/ijms24065366

Perspectives on optimizing local delivery of drugs to peripheral nerves using mathematical models

Added 18 March, 2023

S Laranjeira, VH Roberton, JB Phillips, &RJ Shipley (2023). Perspectives on optimizing local delivery of drugs to peripheral nerves using mathematical models. WIREs Mechanisms of Disease,  15( 2), e1593. https://doi.org/10.1002/wsbm.1593

Local delivery of tacrolimus using electrospun poly-ε-caprolactone nanofibres suppresses the T-cell response to peripheral nerve allografts

Added 23 December, 2022

VH Roberton, HN Gregory, U Angkawinitwong, O Mokrane, AS Boyd, RJ Shipley, GR Williams & JB Phillips (2022). Local delivery of tacrolimus using electrospun poly-ε-caprolactone nanofibres suppresses the T-cell response to peripheral nerve allografts. Journal of Neural Engineering https://doi.org/10.1088/1741-2552/acad2a

Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo

Added 23 December, 2022

MLD Rayner, SC Kellaway, I Kingston, O Guillemot-Legris, H Gregory, J Healy & JB Phillips (2022). Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo. Cells 12, 42 https://doi.org/10.3390/cells12010042

Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves

Added 10 December, 2022

SC Kellaway, V Roberton, JN Jones, R Loczenski, JB Phillips, LJ White (2022). Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2022.12.003

Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer’s disease

Added 19 November, 2022

X Li, T Li, P Zhang, X Li, L Lu, Y Sun, B Zhang, S Allen, L White, J Phillips, Z Zhu, H Yao, J Xu (2022). Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease. European Journal of Medicinal Chemistry 244, 114841

Considerations for the use of biomaterials to support cell therapy in neurodegenerative disease

Added 19 November, 2022

VH Roberton & JB Phillips (2022). Considerations for the use of biomaterials to support cell therapy in neurodegenerative disease. International Review of Neurobiology https://doi.org/10.1016/bs.irn.2022.09.009

A combined experimental and computational framework to evaluate the behavior of therapeutic cells for peripheral nerve regeneration

Added 2 May, 2022

D Eleftheriadou, M Berg, JB Phillips & RJ Shipley (2022). A combined experimental and computational framework to evaluate the behavior of therapeutic cells for peripheral nerve regeneration. Biotechnology & Bioengineering https://doi.org/10.1002/bit.28105

Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer’s disease

Added 25 March, 2022

Y Liu, G Uras, I Onuwaje, W Li, H Yao, S Xu, X Li, X Li, J Phillips, S Allen, Q Gong, H Zhang, Z Zhu, J Liu & J Xu (2022). Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 235, 114305

In silico framework to inform the design of repair constructs for peripheral nerve injury repair

Added 20 March, 2022

S Laranjeira, G Pellegrino, KS Bhangra, JB Phillips & RJ Shipley (2022). In silico framework to inform the design of repair constructs for peripheral nerve injury repair. J R Soc Interface, 19, 20210824

An alginate-based encapsulation system for delivery of therapeutic cells to the CNS

Added 1 February, 2022

D. Eleftheriadou, R.E. Evans, E. Atkinson, A. Abdalla, F.K.H. Gavins, A.S. Boyd, G.R. Williams, J.C. Knowles, V.H. Roberton & J.B. Phillips (2022). An alginate-based encapsulation system for delivery of therapeutic cells to the CNS. RSC Adv. 12, 4005-4015

A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering

Added 20 December, 2021

R.P. Trueman, A. S. Ahlawat & J. B. Phillips (2021). A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering. Tissue Engineering Part B: Reviews http://doi.org/10.1089/ten.TEB.2021.0159

Volumetric MRI is a promising outcome measure of muscle reinnervation

Added 17 November, 2021

M Wilcox, L Dos Santos Canas, R Hargunani, T Tidswell, H Brown, M Modat, J Phillips, S Ourselin & T Quick (2021). Volumetric MRI is a promising outcome measure of muscle reinnervation. Sci Rep 11, 22433 (2021). https://doi.org/10.1038/s41598-021-01342-y

Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model

Added 15 September, 2021

M.L.D. Rayner, A.G.E. Day, K.S. Bhangra, J. Sinden & J.B. Phillips (2021). Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2021.08.030

Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries

Added 1 September, 2021

M.L.D. Rayner, J. Healy & J.B. Phillips (2021). Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries. Biomolecules 2021, 11, 1301

‘EngNT’ — Engineering live neural tissue for nerve replacement

Added 24 July, 2021

J.B. Phillips (2021) ‘EngNT’ — Engineering live neural tissue for nerve replacement. Emerging Topics in Life Sciences ETLS20210085

Modelling-informed cell-seeded nerve repair construct designs for treating peripheral nerve injuries

Added 24 July, 2021

R. Coy, M. Berg, J.B. Phillips & R.J. Shipley (2021) Modelling-informed cell-seeded nerve repair construct designs for treating peripheral nerve injuries. PLoS Computational Biology 17, e1009142

Natural biomaterials as instructive engineered microenvironments that direct cellular function in peripheral nerve tissue engineering

Added 8 June, 2021

R. Powell, D. Eleftheriadou, S. Kellaway & J.B. Phillips (2021) Natural biomaterials as instructive engineered microenvironments that direct cellular function in peripheral nerve tissue engineering. Front. Bioeng. Biotechnol. 9:674473

Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regeneration

Added 8 June, 2021

P. Muangsanit, V. Roberton, E. Costa & J.B. Phillips (2021) Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regeneration. Acta Biomaterialia 126, 224-237

Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers?

Added 8 June, 2021

H. Gregory & J.B. Phillips (2021) Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers? Neurochemistry International 143, 104953

Engineered Tissues Made from Human iPSC-Derived Schwann Cells for Investigating Peripheral Nerve Regeneration In Vitro

Added 15 April, 2021

R. Powell & J.B. Phillips (2021) Engineered Tissues Made from Human iPSC-Derived Schwann Cells for Investigating Peripheral Nerve Regeneration In Vitro. In: Stock P., Christ B. (eds) In Vitro Models for Stem Cell Therapy. Methods in Molecular Biology, vol 2269. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1225-5_17

The molecular profile of nerve repair: humans mirror rodents

Added 30 December, 2020

Wilcox MB, Jessen KR, Quick TJ & Phillips JB (2020). The molecular profile of nerve repair: humans mirror rodents. Neural Regeneration Research, 16, 1440-1441

Strategies for Peripheral Nerve Repair

Added 30 December, 2020

Wilcox M, Gregory H, Powell R, Quick TJ & Phillips JB (2020). Strategies for Peripheral Nerve Repair. Current Tissue Microenvironment Reports 1, 49-59

Three-dimensional culture systems in central nervous system research

Added 30 December, 2020

Onuwaje I & Phillips JB (2020). Three-dimensional culture systems in central nervous system research. Handbook of Innovations in Central Nervous System Regenerative Medicine, 571-601

A Tenon’s capsule/bulbar conjunctiva interface biomimetic to model fibrosis and local drug delivery

Added 30 December, 2020

Kozdon, K, Caridi B, Duru I, Ezra DG, Phillips JB & Bailly M (2020). A Tenon's capsule/bulbar conjunctiva interface biomimetic to model fibrosis and local drug delivery. PLoS ONE, 15(11): e0241569

Perspective on Schwann Cells Derived from Induced Pluripotent Stem Cells in Peripheral Nerve Tissue Engineering

Added 30 December, 2020

Huang Z, Powell R, Phillips JB & Haastert-Talini K (2020). Perspective on Schwann Cells Derived from Induced Pluripotent Stem Cells in Peripheral Nerve Tissue Engineering. Cells, 9, 2497

Microscopic biophysical model of self-organization in tissue due to feedback between cell- and macroscopic-scale forces

Added 30 December, 2020

Hague JP, Mieczkowski PW, O'Rourke C, Loughlin AJ & Phillips JB (2020). Microscopic biophysical model of self-organization in tissue due to feedback between cell- and macroscopic-scale forces. Physical Review Research, 2, 043217

Mechanical properties of the spinal cord and brain: Comparison with clinical-grade biomaterials for tissue engineering and regenerative medicine

Added 28 September, 2020

Bartlett RD, Eleftheriadou D, Evans R, Choi D & Phillips JB (2020). Mechanical properties of the spinal cord and brain: Comparison with clinical-grade biomaterials for tissue engineering and regenerative medicine. Biomaterials 258, 120303

Rapidly formed stable and aligned dense collagen gels seeded with Schwann cells support peripheral nerve regeneration

Added 31 July, 2020

Muangsanit P, Day A, Dimiou S, Ataç A, Kayal C, Park H, Nazhat SN & Phillips JB (2020). Rapidly formed stable and aligned dense collagen gels seeded with Schwann cells support peripheral nerve regeneration. Journal of Neural Engineering https://doi.org/10.1088/1741-2552/abaa9c

Controlled local release of PPARγ agonists from biomaterials to treat peripheral nerve injury

Added 30 July, 2020

Rayner MLD, Grillo A, Williams G, Tawfik E, Zhang T, Volitaki C, Craig DQM, Healy J & Phillips JB (2020) Controlled local release of PPARγ agonists from biomaterials to treat peripheral nerve injury. Journal of Neural Engineering https://doi.org/10.1088/1741-2552/aba7cc

Cell Therapies for Spinal Cord Injury: Trends and Challenges of Current Clinical Trials

Added 18 June, 2020

Bartlett RD, Burley S, Ip M, Phillips JB & Choi D (2020). Cell therapies for spinal cord injury: trends and challenges of current clinical trials. Neurosurgery, nyaa149, https://doi.org/10.1093/neuros/nyaa149

Strategies for Peripheral Nerve Repair

Added 6 May, 2020

Wilcox, M., Gregory, H., Powell, R., Quick T.J. & Phillips, J.B. (2020). Strategies for Peripheral Nerve Repair. Current Tissue Microenvironment Reports https://doi.org/10.1007/s43152-020-00002-z

Characterising cellular and molecular features of human peripheral nerve degeneration

Added 20 April, 2020

Wilcox, M.B., Laranjeira, S.G., Eriksson, T.M., Jessen, K.R., Mirsky, R., Quick, T.J. and Phillips, J.B. (2020). Characterising cellular and molecular features of human peripheral nerve degeneration. Acta Neuropathologica Communications, 8:51 https://doi.org/10.1186/s40478-020-00921-w

Combining in silico and in vitro models to inform cell seeding strategies in tissue engineering

Added 1 April, 2020


Coy R, Al-Badri G, Kayal C, O'Rourke C, Kingham PJ, Phillips JB & Shipley RJ. (2020). Combining in silico and in vitro models to inform cell seeding strategies in tissue engineering. J. R. Soc. Interface. 17. 20190801

Editorial: Peripheral Nerve Regeneration

Added 29 March, 2020

Gambarotta, G., Raimondo, S., Udina, E., Phillips, J.B., Haastert-Talini, K. (2019). Editorial: Peripheral Nerve Regeneration. Frontiers in Cellular Neuroscience, 13 doi:10.3389/fncel.2019.00464 

Improved cell-purification techniques and safety monitoring needed for olfactory ensheathing cell transplantation

Added 29 March, 2020

Bartlett, R., Phillips, J., Choi, D. (2019). Improved cell-purification techniques and safety monitoring needed for olfactory ensheathing cell transplantation. Canadian Medical Association Journal, doi:10.1503/cmaj.73255 

Mechanical response of neural cells to physiologically relevant stiffness gradients

Added 29 March, 2020

Kayal, C., Moeendarbary, E., Shipley, R., Phillips, J. (2019). Mechanical response of neural cells to physiologically relevant stiffness gradients. Advanced Healthcare Materials, doi:10.1002/adhm.201901036

Neural cell responses to wear debris from metal-on-metal total disc replacements

Added 29 March, 2020

Lee, H., Phillips, J.B., Hall, R.M., Tipper, J.L. (2019). Neural cell responses to wear debris from metal-on-metal total disc replacements. European Spine Journal, doi:10.1007/s00586-019-06177-w 

Quantifying regeneration in patients following peripheral nerve injury

Added 16 November, 2019

Rayner MLD, Brown HL, Wilcox M, Phillips JB & Quick TJ (2019). Quantifying regeneration in patients following peripheral nerve injury. JPRAS http://doi.org/10.1016/j.bjps.2019.10.007

Generation of c-MycER-TAM-transduced human late-adherent olfactory mucosa cells for potential regenerative applications

Added 16 November, 2019

Santiago-Toledo G, Georgiou M, dos Reis J, Roberton VH, Valinhas A, Wood RC, Phillips JB, Mason C, Li D, Li Y, Sinden JD, Choi D, Jat PS & Wall IB (2019). Generation of c-MycERTAM-transduced human late-adherent olfactory mucosa cells for potential regenerative applications. Scientific Reports 9, 13190

The Effects of Surgical Antiseptics and Time Delays on RNA Isolated From Human and Rodent Peripheral Nerves

Added 12 September, 2019

Wilcox M, Quick TJ & Phillips JB (2019) The Effects of Surgical Antiseptics and Time Delays on RNA Isolated From Human and Rodent Peripheral Nerves. Frontiers in Cellular Neuroscience 13, 189

Physical and mechanical properties of RAFT-stabilised collagen gels for tissue engineering applications

Added 12 September, 2019

Kayal C, Shipley RJ & Phillips JB (2019) Physical and mechanical properties of RAFT-stabilised collagen gels for tissue engineering applications. Journal of the Mechanical Behaviour of Biomedical Materials 99, 216-224

Developing an in vitro model to screen drugs for nerve regeneration

Added 7 November, 2018

Rayner M, Laranjeira S, Evans RE, Shipley RJ, Healy J & Phillips JB (2018) Developing an in vitro model to screen drugs for nerve regeneration Anatomical Record doi:10.1002/ar.23918

Vascularisation strategies for peripheral nerve tissue engineering

Added 7 November, 2018

Muangsanit P, Shipley RJ & Phillips JB (2018) Vascularisation strategies for peripheral nerve tissue engineering. Anatomical Record doi:10.1002/ar.23919

An optimized collagen-fibrin blend enhances the ability of engineered neural tissue to promote peripheral nerve repair

Added 7 November, 2018

Schuh CMAP, Day AGE, Redl H & Phillips JB (2018) An optimized collagen-fibrin blend enhances the ability of engineered neural tissue to promote peripheral nerve repair. Tissue Engineering Part A, 24, 1332-1340

An allogeneic ‘off the shelf’ therapeutic strategy for peripheral nerve tissue engineering using clinical grade human neural stem cells

Added 13 February, 2018

C. O’Rourke, A. G. E. Day, C. Murray-Dunning, L. Thanabalasundaram, J. Cowan, L. Stevanato, N. Grace, G. Cameron, R. A. L. Drake, J. Sinden & J. B. Phillips (2018) An allogeneic ‘off the shelf’ therapeutic strategy for peripheral nerve tissue engineering using clinical grade human neural stem cells. Scientific Reports 8, 2951

Controlling human corneal stromal stem cell contraction to mediate rapid cell and matrix organization of real architecture for 3-dimensional tissue equivalents

Added 2 February, 2018

Mukhey D, Phillips JB, Daniels JT, Kureshi AK (2018) Controlling human corneal stromal stem cell contraction to mediate rapid cell and matrix organization of real architecture for 3-dimensional tissue equivalents. Acta Biomaterialia. 2018 Feb;67:229-237

Schwann cells and mesenchymal stem cells in laminin- or fibronectin-aligned matrices and regeneration across a critical size defect of 15 mm in the rat sciatic nerve

Added 27 November, 2017

Gonzalez-Perez F, Hernández J, Heimann C, Phillips JB, Udina E, Navarro X (2017) Schwann cells and mesenchymal stem cells in laminin- or fibronectin-aligned matrices and regeneration across a critical size defect of 15 mm in the rat sciatic nerve. Journal of Neurosurgery: Spine, doi: 10.3171/2017.5.SPINE161100

The Effect of Hypothermic and Cryogenic Preservation on Engineered Neural Tissue

Added 27 November, 2017

Day AGE, Bhangra KS, Murray-Dunning C, Stevanato L, Phillips JB (2017) The Effect of Hypothermic and Cryogenic Preservation on Engineered Neural Tissue. Tissue Engineering Part C Methods, 23, 575-582

Low frequency oscillating gradient spin-echo sequences improve sensitivity to axon diameter: An experimental study in viable nerve tissue

Added 17 September, 2017

Kakkar LS, Bennett OF, Siow B, Richardson S, Ianuş A, Quick T, Atkinson D, Phillips JB & Drobnjak I (2017) Low frequency oscillating gradient spin-echo sequences improve sensitivity to axon diameter: An experimental study in viable nerve tissue. NeuroImage https://doi.org/10.1016/j.neuroimage.2017.07.060

Could clinical photochemical internalisation be optimised to avoid neuronal toxicity?

Added 10 June, 2017

C. O’Rourke, C. Hopper, A.J. MacRobert, J.B. Phillips & J.H. Woodhams (2017) Could clinical photochemical internalisation be optimised to avoid neuronal toxicity? International Journal of Pharmaceutics 528, 133-143

Stabilization, rolling and addition of other ECM proteins to collagen hydrogels improves regeneration in chitosan guides for long peripheral nerve gaps in rats

Added 18 April, 2017

F. Gonzalez-Perez, S. Cobianchi, C. Heimann, J.B. Phillips, E. Udina, X. Navarro (2017) Stabilization, rolling and addition of other ECM proteins to collagen hydrogels improves regeneration in chitosan guides for long peripheral nerve gaps in rats. Neurosurgery 80, 465-474

Adapting tissue-engineered in vitro CNS models for high-throughput study of neurodegeneration

Added 22 March, 2017

Caitriona O’Rourke, Charlotte Lee-Reeves, Rosemary AL Drake, Grant WW Cameron, A Jane Laughlin & James B Phillips (2017) Adapting tissue-engineered in vitro CNS models for high-throughput study of neurodegeneration. Journal of Tissue Engineering 8, 1-9.

Combining Gene and Stem Cell Therapy for Peripheral Nerve Tissue Engineering

Added 22 March, 2017

Francesca Busuttil, Ahad A. Rahim and James B. Phillips (2017) Combining gene and stem cell therapy for peripheral nerve tissue engineering. Stem Cells and Development 26(4):231-238

Engineered neural tissue with Schwann cell differentiated human dental pulp stem cells: potential for peripheral nerve repair?

Added 6 January, 2017

K. Sanen, W. Martens, M. Georgiou, M. Ameloot, I. Lambrichts & J.B. Phillips (2017) Engineered neural tissue with Schwann cell differentiated human dental pulp stem cells: potential for peripheral nerve repair? Journal of Tissue Engineering and Regenerative Medicine doi: 10.1002/term.2249

An integrated theoretical-experimental approach to accelerate translational tissue engineering

Added 10 November, 2016

R.H. Coy, O.R. Evans, J.B. Phillips & R.J. Shipley (2016). An integrated theoretical-experimental approach to accelerate translational tissue engineering. Journal of Tissue Engineering and Regenerative Medicine doi: 10.1002/term.2346

Biomechanical properties of the spinal cord: implications for tissue engineering and clinical translation.

Added 12 September, 2016

R.D. Bartlett, D. Choi & J.B. Phillips (2016). Biomechanical properties of the spinal cord: implications for tissue engineering and clinical translation. Regenerative Medicine, (doi:10.2217/rme-2016-0065)

Using Stem Cells to Grow Artificial Tissue for Peripheral Nerve Repair

Added 12 September, 2016

K.S. Bhangra, F. Busuttil, J.B. Phillips & A.A. Rahim (2016). Using Stem Cells to Grow Artificial Tissue for Peripheral Nerve Repair. Stem Cells International, ID 7502178

Label-free mapping of microstructural organisation in self-aligning cellular collagen hydrogels using image correlation spectroscopy

Added 21 November, 2015

K. Sanen, R. Paesen, S. Luyck, J.B. Phillips, I. Lambrichts, W. Martens & M. Ameloot (2015) Label-free mapping of microstructural organisation in self-aligning cellular collagen hydrogels using image correlation spectroscopy. Acts Biomaterialia doi: 10.1016/j.actbio.2015.10.047

Embryonic and mature astrocytes exert different effects on neuronal growth in rat ventral mesencephalic slice cultures

Added 21 November, 2015

Hashemian, C. O'Rourke, J.B. Phillips, I. Strömberg & S. Af Bjerkén (2015) Embryonic and mature astrocytes exert different effects on neuronal growth in rat ventral mesencephalic slice cultures. Springerplus doi: 10.1186/s40064-015-1362-3

Optimising contraction and alignment of cellular collagen hydrogels to achieve reliable and consistent engineered anisotropic tissue.

Added 20 October, 2015

O'Rourke, Caitriona; Drake, Rosemary A. L.; Cameron, Grant W. W.; Loughlin, A. Jane and Phillips, James B. (2015). Optimising contraction and alignment of cellular collagen hydrogels to achieve reliable and consistent engineered anisotropic tissue. Journal of Biomaterials Applications (Early view).

Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve.

Added 11 November, 2014

Melanie Georgiou, Jon P. Golding, Alison J. Loughlin, Paul J. Kingham and James B. Phillips (2015). Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve. Biomaterials, 37 pp. 242–251.

A three-dimensional collagen construct to model lipopolysaccharide-induced activation of BV2 microglia

Added 7 August, 2014

Haw, Randy Tatt; Tong, Chih Kong; Yew, Andrew; Lee, Han Chung; Phillips, James B. and Vidyadaran, Sharmili (2014). A three-dimensional collagen construct to model lipopolysaccharide-induced activation of BV2 microglia. Journal of Neuroinflammation, 11, article no. 134.

Monitoring neuron and astrocyte interactions with a 3D cell culture system

Added 6 August, 2014

Phillips, James B. (2014). Monitoring neuron and astrocyte interactions with a 3D cell culture system. In: Murray, Andrew J. ed. Axon Growth and Regeneration: Methods and Regeneration. Methods in Molecular Biology: Methods and Protocols, 1162. New York: Springer, pp. 113–124.

Building stable anisotropic tissues using cellular collagen gels

Added 11 February, 2014

Phillips, James B. (2014). Building stable anisotropic tissues using cellular collagen gels. Organogenesis, 10(1) pp. 6–8.

Human dental pulp stem cells can differentiate into Schwann cells and promote and guide neurite outgrowth in an aligned tissue-engineered collagen construct in vitro

Added 23 December, 2013

Martens, Wendy ; Sanen, Kathleen ; Georgiou, Melanie ; Struys, Tom; Bronckaers, Annelies; Ameloot, Marcel; Phillips, James and Lambrichts, Ivo (2014). Human dental pulp stem cells can differentiate into Schwann cells and promote and guide neurite outgrowth in an aligned tissue-engineered collagen construct in vitro. FASEB Journal, 28(4) pp. 1634–1643.

Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro

Added 11 December, 2013

Gromnicova, Radka ; Davies, Heather A. ; Sreekanthreddy, Pedagannganagari ; Romero, Ignacio A. ; Lund, Torben; Roitt, Ivan M.; Phillips, James B. and Male, David K. (2013). Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro. PLoS ONE, 8(12), article no. e81043.

A 3D in vitro model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury

Added 25 October, 2013

East, Emma ; Johns, Noemie ; Georgiou, Melanie ; Golding, Jon ; Loughlin, Jane ; Kingham, Paul and Phillips, James (2013). A 3D in vitro model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury. Regenerative Medicine, 8(6) pp. 739–746.

Targeting tumour energy metabolism potentiates the cytotoxicity of 5-aminolevulinic acid photodynamic therapy

Added 24 July, 2013

Golding, J. P. ; Wardhaugh, T. ; Patrick, L.; Turner, M.; Phillips, J. B. ; Bruce, J. I. and Kimani, S. G. (2013). Targeting tumour energy metabolism potentiates the cytotoxicity of 5-aminolevulinic acid photodynamic therapy. British Journal of Cancer, 109(4) pp. 976–982.

Engineered neural tissue for peripheral nerve repair

Added 9 July, 2013

Georgiou, Melanie ; Bunting, Stephen C. J. ; Davies, Heather A. ; Loughlin, Alison J. ; Golding, Jonathan P. and Phillips, James B. (2013). Engineered neural tissue for peripheral nerve repair. Biomaterials, 34(30) pp. 7335–7343.

Fully protected glycosylated zinc (II) phthalocyanine shows high uptake and photodynamic cytotoxicity in MCF-7 cancer cells

Added 26 July, 2012

Kimani, Stanley ; Shmigol, Tatiana; Hammond, Samantha ; Phillips, James B. ; Bruce, James I. ; MacRobert, Alexander J.; Malakhov, Mikhail V. and Golding, Jon P. (2013). Fully protected glycosylated zinc (II) phthalocyanine shows high uptake and photodynamic cytotoxicity in MCF-7 cancer cells. Photochemistry and Photobiology, 89(1) pp. 139–149.

Micro-structured materials and mechanical cues in 3D collagen gels

Added 19 July, 2012

Phillips, James and Brown, Robert (2010). Micro-structured materials and mechanical cues in 3D collagen gels. In: Haycock, John W. ed. 3D Cell Culture. Methods in Molecular Biology (695). New York: Humana Press, pp. 183–196.

Inhibition of specific cellular antioxidant pathways increases the sensitivity of neurons to meta-tetrahydroxyphenyl chlorin-mediated photodynamic therapy in a 3D co-culture model

Added 11 July, 2012

Wright, Kathleen E. ; MacRobert, Alexander J. and Phillips, James B. (2012). Inhibition of specific cellular antioxidant pathways increases the sensitivity of neurons to meta-tetrahydroxyphenyl chlorin-mediated photodynamic therapy in a 3D co-culture model. Photochemistry and Photobiology, 88 pp. 1539–1545.

Engineering an integrated cellular interface in three-dimensional hydrogel cultures permits monitoring of reciprocal astrocyte and neuronal responses

Added 15 February, 2012

East, Emma ; Golding, Jon P. and Phillips, James B. (2012). Engineering an integrated cellular interface in three-dimensional hydrogel cultures permits monitoring of reciprocal astrocyte and neuronal responses. Tissue Engineering Part C: Methods, 18(7) pp. 526–536.

Antioxidant inhibitors potentiate the cytotoxicity of photodynamic therapy

Added 16 November, 2011

Kimani, Stanley G. ; Phillips, James B. ; Bruce, James I. ; MacRobert, Alexander J. and Golding, Jon P. (2012). Antioxidant inhibitors potentiate the cytotoxicity of photodynamic therapy. Photochemistry and Photobiology, 88(1) pp. 175–187.

An ultrastructural and biochemical analysis of collagen in rat peripheral nerves: the relationship between fibril diameter and mechanical properties

Added 21 October, 2011

Mason, Sarah and Phillips, James (2011). An ultrastructural and biochemical analysis of collagen in rat peripheral nerves: the relationship between fibril diameter and mechanical properties. Journal of the Peripheral Nervous System, 16(3) pp. 261–269.

Micro-structured materials and mechanical cues in 3D collagen gels

Added 21 January, 2011

Phillips, James and Brown, Robert (2010). Micro-structured materials and mechanical cues in 3D collagen gels. In: Haycock, John W. ed. 3D Cell Culture. Methods in Molecular Biology (695). New York: Humana Press (Springer Verlag), pp. 183–196.

Alignment of astrocytes increases neuronal growth in three-dimensional collagen gels and is maintained following plastic compression to form a spinal cord repair conduit

Added 18 August, 2010

East, Emma ; Blum de Oliveira, Daniela; Golding, Jon P. and Phillips, James B. (2010). Alignment of astrocytes increases neuronal growth in three-dimensional collagen gels and is maintained following plastic compression to form a spinal cord repair conduit. Tissue Engineering Part A, 16(10) pp. 3173–3184.

The neuroprotective effects of fibronectin mats and fibronectin peptides following spinal cord injury in the rat

Added 28 May, 2010

King, V. R.; Hewazy, D.; Alovskaya, A.; Phillips, J. B. ; Brown, R. A. and Priestley, J. V. (2010). The neuroprotective effects of fibronectin mats and fibronectin peptides following spinal cord injury in the rat. Neuroscience, 168(2) pp. 523–530.

A versatile 3D culture model facilitates monitoring of astrocytes undergoing reactive gliosis

Added 21 October, 2009

East, Emma ; Golding, Jonathan P. and Phillips, James B. (2009). A versatile 3D culture model facilitates monitoring of astrocytes undergoing reactive gliosis. Journal of Tissue Engineering and Regenerative Medicine, 3(8) pp. 634–646.

Investigating the mechanical shear-plane between core and sheath elements of peripheral nerves

Added 16 September, 2009

Georgeu, G. A.; Walbeehm, E. T.; Tillett, R.; Afoke, A.; Brown, R. A. and Phillips, J. B. (2005). Investigating the mechanical shear-plane between core and sheath elements of peripheral nerves. Cell and Tissue Research, 320(2) pp. 229–234.

Host muscle cell infiltration in cell-seeded plastic compressed collagen constructs.

Added 7 September, 2009

H. Kayhanian, S. Jones, J.B. Phillips, M. Lewis, R. Brown and V. Mudera (2009) Host muscle cell infiltration in cell-seeded plastic compressed collagen constructs. Journal of Tissue Engineering and Regenerative Medicine, 3, 72-75.

Peripheral neural cell sensitivity to mTHPC-mediated photodynamic therapy in a 3D in vitro model

Added 30 July, 2009

Wright, K. E. ; Liniker, E.; Loizidou, M.; Moore, C.; MacRobert, A. J. and Phillips, J. B. (2009). Peripheral neural cell sensitivity to mTHPC-mediated photodynamic therapy in a 3D in vitro model. British Journal of Cancer, 101(4) pp. 658–665.

Host muscle cell infiltration in cell-seeded plastic compressed collagen constructs

Added 19 November, 2008

Kayhanian, Hamzeh; Jones, Stephanie; Phillips, James ; Lewis, Mark; Brown, Robert and Mudera, Vivek (2009). Host muscle cell infiltration in cell-seeded plastic compressed collagen constructs. Journal of Tissue Engineering and Regenerative Medicine, 3(1) pp. 72–75.

Tissue engineered cell culture models for nervous system research

Added 20 October, 2008

East, Emma and Phillips, James B. (2008). Tissue engineered cell culture models for nervous system research. In: Greco, Giovanni N. ed. Tissue Engineering Research Trends. Nova Science Publishers, Inc, pp. 141–160.

Fibronectin, Collagen, Fibrin – Components of Extracellular Matrix for Nerve Regeneration

Added 26 September, 2007

Alovskaya, A; Alekseeva, T; Phillips, JB; King, V and Brown, R (2007). Fibronectin, Collagen, Fibrin - Components of Extracellular Matrix for Nerve Regeneration. In: Ashammakhi, N.; Reis, R. L. and Chiellini, E. eds. Topics in tissue engineering, Volume 3. Biomaterials and Tissue Engineering Group.

Cell responses to biomimetic protein scaffolds used in tissue repair and engineering

Added 27 June, 2007

Brown, Robert A. and Phillips, James B. (2007). Cell responses to biomimetic protein scaffolds used in tissue repair and engineering. International Review of Cytology, 262 pp. 75–150.

Characterization of non-neuronal elements within fibronectin mats implanted into the damaged spinal cord

Added 7 May, 2006

V.R. King, J.B. Phillips, H. Hunt-Grubbe, R. Brown, and J.V. Priestley (2006) Characterization of non-neuronal elements within fibronectin mats implanted into the damaged spinal cord. Biomaterials 27, 485-496.

Serum deprivation and re-addition: Effects on cyclooxygenase inhibitor sensitivity in cultured glia

Added 6 February, 2005

J.B. Phillips and B. Pearce (2005) Serum deprivation and re-addition: Effects on cyclooxygenase inhibitor sensitivity in cultured glia. Inflammopharmacology 13, 431-439.

Neural tissue engineering: A self-organizing collagen guidance conduit.

Added 6 January, 2005

J.B. Phillips, S. Bunting, S.M. Hall and R.A. Brown (2005) Neural tissue engineering: A self-organizing collagen guidance conduit. Tissue Engineering 11, 1611-1617

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