Publications
Some of our recent publications are listed below. To find more please visit UCL IRIS
Latest Papers
Automated production of nerve repair constructs containing endothelial cell tube-like structures
Added 23 November, 2024
PO Smith, G Huang, K Devries, SN Nazhat & JB Phillips (2024) Automated production of nerve repair constructs containing endothelial cell tube-like structures. Biofabrication 17 https://doi.org/10.1088/1758-5090/ad8efd
Biofabrication and biomanufacturing in Ireland and the UK
Added 23 November, 2024
JF Murphy, M Lavelle, L Asciak, R Burdis, HJ Levis, C Ligorio, J McGuire, M Polleres, PO Smith, L Tullie, J Uribe-Gomez, B Chen, JI Dawson, JE Gautrot, NM Hooper, DJ Kelly, VSW Li, A Mata, A Pandit, JB Phillips, W Shu, MM Stevens, RL Williams, JPK Armstrong & YYS Huang (2024) Biofabrication and biomanufacturing in Ireland and the UK. Bio-Design and Manufacturing https://doi.org/10.1007/s42242-024-00316-z
In silico model for automated calculation of functional metrics in animal models of peripheral nerve injury repair
Added 11 October, 2024
S Laranjeira, O Guillemot-Legris, G Girmahun, V Roberton, JB Phillips, RJ Shipley (2024) In silico model for automated calculation of functional metrics in animal models of peripheral nerve injury repair.
Computers in Biology and Medicine 181, 109036 https://doi.org/10.1016/j.compbiomed.2024.109036
Formation of vascular-like structures using a chemotaxis-driven multiphase model
Added 11 October, 2024
G Al-Badri, JB Phillips, RJ. Shipley & NC Ovenden (2024) Formation of vascular-like structures using a chemotaxis-driven multiphase model. Mathematical Biosciences 372, 109183 https://doi.org/10.1016/j.mbs.2024.109183
Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing
Added 3 March, 2024
RP Trueman, O Guillemot-Legris, HT Lancashire, AS Mehta, J Tropp, RE Daso, J Rivnay, AB Tabor, JB Phillips & BC Schroeder (2024). Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing. Advanced Engineering Materials, e2301488. 10.1002/adem.202301488.
Electrospun polyvinylidene fluoride with novel facile synthesized functionalized boron nitride quantum dots for neural applications
Added 3 March, 2024
B Ekram, RP Trueman, JB Phillips, H Ros, BM Abd El-Hady, D El-Gendy (2024) Electrospun polyvinylidene fluoride with novel facile synthesized functionalized boron nitride quantum dots for neural applications. Polymer Engineering and Science 10.1002/pen.26632.
Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair
Added 12 October, 2023
HN Gregory, O Guillemot-Legris, D Crouch, G Williams & JB Phillips (2023) Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair. Regenerative Medicine https://doi.org/10.2217/rme-2023-0151
Development of ibuprofen-loaded electrospun materials suitable for surgical implantation in peripheral nerve injury
Added 12 October, 2023
K Dziemidowicz, SC Kellaway, O Guillemot-Legris, O Matar, R Pereira Trindade, VH Roberton, MLD Rayner, GR Williams & JB Phillips (2023) Development of ibuprofen-loaded electrospun materials suitable for surgical implantation in peripheral nerve injury. Biomaterials Advances 154, 213623, https://doi.org/10.1016/j.bioadv.2023.213623
Mathematical modelling with Bayesian inference to quantitatively characterize therapeutic cell behaviour in nerve tissue engineering
Added 12 October, 2023
M Berg, D Eleftheriadou, JB Phillips & RJ Shipley (2023) Mathematical modelling with Bayesian inference to quantitatively characterize therapeutic cell behaviour in nerve tissue engineering. Journal of the Royal Society Interface, 20 (206), 20230258. 10.1098/rsif.2023.0258.
Local Administration of Minocycline Improves Nerve Regeneration in Two Rat Nerve Injury Models
Added 30 July, 2023
O Guillemot-Legris, G Girmahun, RJ Shipley & JB Phillips (2023). Local Administration of Minocycline Improves Nerve Regeneration in Two Rat Nerve Injury Models. Int J Mol Sci 24, 12085
Serum neurofilament light chain measurements following nerve trauma
Added 30 July, 2023
M Wilcox, MLD Rayner, O Guillemot-Legris, I Platt, H Brown, T Quick & JB Phillips (2023). Serum neurofilament light chain measurements following nerve trauma. J Peripher Nerv Syst. https://doi.org/10.1111/jns.12576
Improving the biological interfacing capability of diketopyrrolopyrrole polymers via p-type doping
Added 30 July, 2023
RP Trueman, PG Finn, MM Westwood, A Dey, R Palgrave, A Tabor, JB Phillips & BC Schroeder (2023). Improving the biological interfacing capability of diketopyrrolopyrrole polymers via p-type doping. J Mater Chem C Mater 11, 6943-6950
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Added 28 May, 2023
G Gong, B Bilanges, B Allsop, GR Masson, V Roberton, T Askwith, S Oxenford, RR Madsen, SE Conduit, D Bellini, M Fitzek, M Collier, O Najam, Z He, B Wahab, SH McLaughlin, AWE Chan, I Feierberg, A Madin, D Morelli, A Bhamra, V Vinciauskaite, KE Anderson, S Surinova, N Pinotsis, E Lopez-Guadamillas, M Wilcox, A Hooper, C Patel, MA Whitehead, TD Bunney, LR Stephens, PT Hawkins, M Katan, DM Yellon, SM Davidson, DM Smith, JB Phillips, R Angell, RL Williams & B Vanhaesebroeck (2023). A small-molecule PI3Kα activator for cardioprotection and neuroregeneration. Nature https://doi.org/10.1038/s41586-023-05972-2
Exploring the Effect of Vitamins B1, B6 and B12 on Neurite Regeneration using a 3D Co-Culture Model of Neurodegeneration
Added 19 May, 2023
PO Smith, RP Trueman, R Powell, H Gregory, JB Phillips, P Bohnhorst & MLD Rayner (2023). Exploring the Effect of Vitamins B1, B6 and B12 on Neurite Regeneration using a 3D Co-Culture Model of Neurodegeneration. International Journal of Physical Medicine & Rehabilitation 11, 1000667
Culture Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-Centre Study
Added 18 March, 2023
Z Huang, R Powell, S Kankowski, JB Phillips & K Haastert-Talini (2023). Culture Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-Centre Study. International Journal of Molecular Sciences 24(6), 5366. https://doi.org/10.3390/ijms24065366
Perspectives on optimizing local delivery of drugs to peripheral nerves using mathematical models
Added 18 March, 2023
S Laranjeira, VH Roberton, JB Phillips, &RJ Shipley (2023). Perspectives on optimizing local delivery of drugs to peripheral nerves using mathematical models. WIREs Mechanisms of Disease, 15( 2), e1593. https://doi.org/10.1002/wsbm.1593
Local delivery of tacrolimus using electrospun poly-ε-caprolactone nanofibres suppresses the T-cell response to peripheral nerve allografts
Added 23 December, 2022
VH Roberton, HN Gregory, U Angkawinitwong, O Mokrane, AS Boyd, RJ Shipley, GR Williams & JB Phillips (2022). Local delivery of tacrolimus using electrospun poly-ε-caprolactone nanofibres suppresses the T-cell response to peripheral nerve allografts. Journal of Neural Engineering https://doi.org/10.1088/1741-2552/acad2a
Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo
Added 23 December, 2022
MLD Rayner, SC Kellaway, I Kingston, O Guillemot-Legris, H Gregory, J Healy & JB Phillips (2022). Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo. Cells 12, 42 https://doi.org/10.3390/cells12010042
Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves
Added 10 December, 2022
SC Kellaway, V Roberton, JN Jones, R Loczenski, JB Phillips, LJ White (2022). Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2022.12.003
Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer’s disease
Added 19 November, 2022
X Li, T Li, P Zhang, X Li, L Lu, Y Sun, B Zhang, S Allen, L White, J Phillips, Z Zhu, H Yao, J Xu (2022). Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease. European Journal of Medicinal Chemistry 244, 114841
Considerations for the use of biomaterials to support cell therapy in neurodegenerative disease
Added 19 November, 2022
VH Roberton & JB Phillips (2022). Considerations for the use of biomaterials to support cell therapy in neurodegenerative disease. International Review of Neurobiology https://doi.org/10.1016/bs.irn.2022.09.009
A combined experimental and computational framework to evaluate the behavior of therapeutic cells for peripheral nerve regeneration
Added 2 May, 2022
D Eleftheriadou, M Berg, JB Phillips & RJ Shipley (2022). A combined experimental and computational framework to evaluate the behavior of therapeutic cells for peripheral nerve regeneration. Biotechnology & Bioengineering https://doi.org/10.1002/bit.28105
Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer’s disease
Added 25 March, 2022
Y Liu, G Uras, I Onuwaje, W Li, H Yao, S Xu, X Li, X Li, J Phillips, S Allen, Q Gong, H Zhang, Z Zhu, J Liu & J Xu (2022). Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 235, 114305
In silico framework to inform the design of repair constructs for peripheral nerve injury repair
Added 20 March, 2022
S Laranjeira, G Pellegrino, KS Bhangra, JB Phillips & RJ Shipley (2022). In silico framework to inform the design of repair constructs for peripheral nerve injury repair. J R Soc Interface, 19, 20210824
An alginate-based encapsulation system for delivery of therapeutic cells to the CNS
Added 1 February, 2022
D. Eleftheriadou, R.E. Evans, E. Atkinson, A. Abdalla, F.K.H. Gavins, A.S. Boyd, G.R. Williams, J.C. Knowles, V.H. Roberton & J.B. Phillips (2022). An alginate-based encapsulation system for delivery of therapeutic cells to the CNS. RSC Adv. 12, 4005-4015
A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering
Added 20 December, 2021
R.P. Trueman, A. S. Ahlawat & J. B. Phillips (2021). A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering. Tissue Engineering Part B: Reviews http://doi.org/10.1089/ten.TEB.2021.0159
Volumetric MRI is a promising outcome measure of muscle reinnervation
Added 17 November, 2021
M Wilcox, L Dos Santos Canas, R Hargunani, T Tidswell, H Brown, M Modat, J Phillips, S Ourselin & T Quick (2021). Volumetric MRI is a promising outcome measure of muscle reinnervation. Sci Rep 11, 22433 (2021). https://doi.org/10.1038/s41598-021-01342-y
Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model
Added 15 September, 2021
M.L.D. Rayner, A.G.E. Day, K.S. Bhangra, J. Sinden & J.B. Phillips (2021). Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2021.08.030
Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries
Added 1 September, 2021
M.L.D. Rayner, J. Healy & J.B. Phillips (2021). Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries. Biomolecules 2021, 11, 1301
‘EngNT’ — Engineering live neural tissue for nerve replacement
Added 24 July, 2021
J.B. Phillips (2021) ‘EngNT’ — Engineering live neural tissue for nerve replacement. Emerging Topics in Life Sciences ETLS20210085
Modelling-informed cell-seeded nerve repair construct designs for treating peripheral nerve injuries
Added 24 July, 2021
R. Coy, M. Berg, J.B. Phillips & R.J. Shipley (2021) Modelling-informed cell-seeded nerve repair construct designs for treating peripheral nerve injuries. PLoS Computational Biology 17, e1009142
Natural biomaterials as instructive engineered microenvironments that direct cellular function in peripheral nerve tissue engineering
Added 8 June, 2021
R. Powell, D. Eleftheriadou, S. Kellaway & J.B. Phillips (2021) Natural biomaterials as instructive engineered microenvironments that direct cellular function in peripheral nerve tissue engineering. Front. Bioeng. Biotechnol. 9:674473
Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regeneration
Added 8 June, 2021
P. Muangsanit, V. Roberton, E. Costa & J.B. Phillips (2021) Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regeneration. Acta Biomaterialia 126, 224-237
Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers?
Added 8 June, 2021
H. Gregory & J.B. Phillips (2021) Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers? Neurochemistry International 143, 104953
Engineered Tissues Made from Human iPSC-Derived Schwann Cells for Investigating Peripheral Nerve Regeneration In Vitro
Added 15 April, 2021
R. Powell & J.B. Phillips (2021) Engineered Tissues Made from Human iPSC-Derived Schwann Cells for Investigating Peripheral Nerve Regeneration In Vitro. In: Stock P., Christ B. (eds) In Vitro Models for Stem Cell Therapy. Methods in Molecular Biology, vol 2269. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1225-5_17
The molecular profile of nerve repair: humans mirror rodents
Added 30 December, 2020
Wilcox MB, Jessen KR, Quick TJ & Phillips JB (2020). The molecular profile of nerve repair: humans mirror rodents. Neural Regeneration Research, 16, 1440-1441
Strategies for Peripheral Nerve Repair
Added 30 December, 2020
Wilcox M, Gregory H, Powell R, Quick TJ & Phillips JB (2020). Strategies for Peripheral Nerve Repair. Current Tissue Microenvironment Reports 1, 49-59
Three-dimensional culture systems in central nervous system research
Added 30 December, 2020
Onuwaje I & Phillips JB (2020). Three-dimensional culture systems in central nervous system research. Handbook of Innovations in Central Nervous System Regenerative Medicine, 571-601
A Tenon’s capsule/bulbar conjunctiva interface biomimetic to model fibrosis and local drug delivery
Added 30 December, 2020
Kozdon, K, Caridi B, Duru I, Ezra DG, Phillips JB & Bailly M (2020). A Tenon's capsule/bulbar conjunctiva interface biomimetic to model fibrosis and local drug delivery. PLoS ONE, 15(11): e0241569
Perspective on Schwann Cells Derived from Induced Pluripotent Stem Cells in Peripheral Nerve Tissue Engineering
Added 30 December, 2020
Huang Z, Powell R, Phillips JB & Haastert-Talini K (2020). Perspective on Schwann Cells Derived from Induced Pluripotent Stem Cells in Peripheral Nerve Tissue Engineering. Cells, 9, 2497
Microscopic biophysical model of self-organization in tissue due to feedback between cell- and macroscopic-scale forces
Added 30 December, 2020
Hague JP, Mieczkowski PW, O'Rourke C, Loughlin AJ & Phillips JB (2020). Microscopic biophysical model of self-organization in tissue due to feedback between cell- and macroscopic-scale forces. Physical Review Research, 2, 043217
Mechanical properties of the spinal cord and brain: Comparison with clinical-grade biomaterials for tissue engineering and regenerative medicine
Added 28 September, 2020
Bartlett RD, Eleftheriadou D, Evans R, Choi D & Phillips JB (2020). Mechanical properties of the spinal cord and brain: Comparison with clinical-grade biomaterials for tissue engineering and regenerative medicine. Biomaterials 258, 120303
Rapidly formed stable and aligned dense collagen gels seeded with Schwann cells support peripheral nerve regeneration
Added 31 July, 2020
Muangsanit P, Day A, Dimiou S, Ataç A, Kayal C, Park H, Nazhat SN & Phillips JB (2020). Rapidly formed stable and aligned dense collagen gels seeded with Schwann cells support peripheral nerve regeneration. Journal of Neural Engineering https://doi.org/10.1088/1741-2552/abaa9c
Controlled local release of PPARγ agonists from biomaterials to treat peripheral nerve injury
Added 30 July, 2020
Rayner MLD, Grillo A, Williams G, Tawfik E, Zhang T, Volitaki C, Craig DQM, Healy J & Phillips JB (2020) Controlled local release of PPARγ agonists from biomaterials to treat peripheral nerve injury. Journal of Neural Engineering https://doi.org/10.1088/1741-2552/aba7cc
Cell Therapies for Spinal Cord Injury: Trends and Challenges of Current Clinical Trials
Added 18 June, 2020
Bartlett RD, Burley S, Ip M, Phillips JB & Choi D (2020). Cell therapies for spinal cord injury: trends and challenges of current clinical trials. Neurosurgery, nyaa149, https://doi.org/10.1093/neuros/nyaa149
Strategies for Peripheral Nerve Repair
Added 6 May, 2020
Wilcox, M., Gregory, H., Powell, R., Quick T.J. & Phillips, J.B. (2020). Strategies for Peripheral Nerve Repair. Current Tissue Microenvironment Reports https://doi.org/10.1007/s43152-020-00002-z
Characterising cellular and molecular features of human peripheral nerve degeneration
Added 20 April, 2020
Wilcox, M.B., Laranjeira, S.G., Eriksson, T.M., Jessen, K.R., Mirsky, R., Quick, T.J. and Phillips, J.B. (2020). Characterising cellular and molecular features of human peripheral nerve degeneration. Acta Neuropathologica Communications, 8:51 https://doi.org/10.1186/s40478-020-00921-w
Combining in silico and in vitro models to inform cell seeding strategies in tissue engineering
Added 1 April, 2020
Coy R, Al-Badri G, Kayal C, O'Rourke C, Kingham PJ, Phillips JB & Shipley RJ. (2020). Combining in silico and in vitro models to inform cell seeding strategies in tissue engineering. J. R. Soc. Interface. 17. 20190801
Editorial: Peripheral Nerve Regeneration
Added 29 March, 2020
Gambarotta, G., Raimondo, S., Udina, E., Phillips, J.B., Haastert-Talini, K. (2019). Editorial: Peripheral Nerve Regeneration. Frontiers in Cellular Neuroscience, 13 doi:10.3389/fncel.2019.00464
Improved cell-purification techniques and safety monitoring needed for olfactory ensheathing cell transplantation
Added 29 March, 2020
Bartlett, R., Phillips, J., Choi, D. (2019). Improved cell-purification techniques and safety monitoring needed for olfactory ensheathing cell transplantation. Canadian Medical Association Journal, doi:10.1503/cmaj.73255
Mechanical response of neural cells to physiologically relevant stiffness gradients
Added 29 March, 2020
Kayal, C., Moeendarbary, E., Shipley, R., Phillips, J. (2019). Mechanical response of neural cells to physiologically relevant stiffness gradients. Advanced Healthcare Materials, doi:10.1002/adhm.201901036
Neural cell responses to wear debris from metal-on-metal total disc replacements
Added 29 March, 2020
Lee, H., Phillips, J.B., Hall, R.M., Tipper, J.L. (2019). Neural cell responses to wear debris from metal-on-metal total disc replacements. European Spine Journal, doi:10.1007/s00586-019-06177-w
Quantifying regeneration in patients following peripheral nerve injury
Added 16 November, 2019
Rayner MLD, Brown HL, Wilcox M, Phillips JB & Quick TJ (2019). Quantifying regeneration in patients following peripheral nerve injury. JPRAS http://doi.org/10.1016/j.bjps.2019.10.007
Generation of c-MycER-TAM-transduced human late-adherent olfactory mucosa cells for potential regenerative applications
Added 16 November, 2019
Santiago-Toledo G, Georgiou M, dos Reis J, Roberton VH, Valinhas A, Wood RC, Phillips JB, Mason C, Li D, Li Y, Sinden JD, Choi D, Jat PS & Wall IB (2019). Generation of c-MycERTAM-transduced human late-adherent olfactory mucosa cells for potential regenerative applications. Scientific Reports 9, 13190
The Effects of Surgical Antiseptics and Time Delays on RNA Isolated From Human and Rodent Peripheral Nerves
Added 12 September, 2019
Wilcox M, Quick TJ & Phillips JB (2019) The Effects of Surgical Antiseptics and Time Delays on RNA Isolated From Human and Rodent Peripheral Nerves. Frontiers in Cellular Neuroscience 13, 189
Physical and mechanical properties of RAFT-stabilised collagen gels for tissue engineering applications
Added 12 September, 2019
Kayal C, Shipley RJ & Phillips JB (2019) Physical and mechanical properties of RAFT-stabilised collagen gels for tissue engineering applications. Journal of the Mechanical Behaviour of Biomedical Materials 99, 216-224
Developing an in vitro model to screen drugs for nerve regeneration
Added 7 November, 2018Rayner M, Laranjeira S, Evans RE, Shipley RJ, Healy J & Phillips JB (2018) Developing an in vitro model to screen drugs for nerve regeneration Anatomical Record doi:10.1002/ar.23918
Vascularisation strategies for peripheral nerve tissue engineering
Added 7 November, 2018Muangsanit P, Shipley RJ & Phillips JB (2018) Vascularisation strategies for peripheral nerve tissue engineering. Anatomical Record doi:10.1002/ar.23919
An optimized collagen-fibrin blend enhances the ability of engineered neural tissue to promote peripheral nerve repair
Added 7 November, 2018Schuh CMAP, Day AGE, Redl H & Phillips JB (2018) An optimized collagen-fibrin blend enhances the ability of engineered neural tissue to promote peripheral nerve repair. Tissue Engineering Part A, 24, 1332-1340
An allogeneic ‘off the shelf’ therapeutic strategy for peripheral nerve tissue engineering using clinical grade human neural stem cells
Added 13 February, 2018C. O’Rourke, A. G. E. Day, C. Murray-Dunning, L. Thanabalasundaram, J. Cowan, L. Stevanato, N. Grace, G. Cameron, R. A. L. Drake, J. Sinden & J. B. Phillips (2018) An allogeneic ‘off the shelf’ therapeutic strategy for peripheral nerve tissue engineering using clinical grade human neural stem cells. Scientific Reports 8, 2951
Controlling human corneal stromal stem cell contraction to mediate rapid cell and matrix organization of real architecture for 3-dimensional tissue equivalents
Added 2 February, 2018Mukhey D, Phillips JB, Daniels JT, Kureshi AK (2018) Controlling human corneal stromal stem cell contraction to mediate rapid cell and matrix organization of real architecture for 3-dimensional tissue equivalents. Acta Biomaterialia. 2018 Feb;67:229-237
Schwann cells and mesenchymal stem cells in laminin- or fibronectin-aligned matrices and regeneration across a critical size defect of 15 mm in the rat sciatic nerve
Added 27 November, 2017Gonzalez-Perez F, Hernández J, Heimann C, Phillips JB, Udina E, Navarro X (2017) Schwann cells and mesenchymal stem cells in laminin- or fibronectin-aligned matrices and regeneration across a critical size defect of 15 mm in the rat sciatic nerve. Journal of Neurosurgery: Spine, doi: 10.3171/2017.5.SPINE161100
The Effect of Hypothermic and Cryogenic Preservation on Engineered Neural Tissue
Added 27 November, 2017Day AGE, Bhangra KS, Murray-Dunning C, Stevanato L, Phillips JB (2017) The Effect of Hypothermic and Cryogenic Preservation on Engineered Neural Tissue. Tissue Engineering Part C Methods, 23, 575-582
Low frequency oscillating gradient spin-echo sequences improve sensitivity to axon diameter: An experimental study in viable nerve tissue
Added 17 September, 2017Kakkar LS, Bennett OF, Siow B, Richardson S, Ianuş A, Quick T, Atkinson D, Phillips JB & Drobnjak I (2017) Low frequency oscillating gradient spin-echo sequences improve sensitivity to axon diameter: An experimental study in viable nerve tissue. NeuroImage https://doi.org/10.1016/j.neuroimage.2017.07.060
Could clinical photochemical internalisation be optimised to avoid neuronal toxicity?
Added 10 June, 2017C. O’Rourke, C. Hopper, A.J. MacRobert, J.B. Phillips & J.H. Woodhams (2017) Could clinical photochemical internalisation be optimised to avoid neuronal toxicity? International Journal of Pharmaceutics 528, 133-143
Stabilization, rolling and addition of other ECM proteins to collagen hydrogels improves regeneration in chitosan guides for long peripheral nerve gaps in rats
Added 18 April, 2017F. Gonzalez-Perez, S. Cobianchi, C. Heimann, J.B. Phillips, E. Udina, X. Navarro (2017) Stabilization, rolling and addition of other ECM proteins to collagen hydrogels improves regeneration in chitosan guides for long peripheral nerve gaps in rats. Neurosurgery 80, 465-474
Adapting tissue-engineered in vitro CNS models for high-throughput study of neurodegeneration
Added 22 March, 2017Caitriona O’Rourke, Charlotte Lee-Reeves, Rosemary AL Drake, Grant WW Cameron, A Jane Laughlin & James B Phillips (2017) Adapting tissue-engineered in vitro CNS models for high-throughput study of neurodegeneration. Journal of Tissue Engineering 8, 1-9.
Combining Gene and Stem Cell Therapy for Peripheral Nerve Tissue Engineering
Added 22 March, 2017Francesca Busuttil, Ahad A. Rahim and James B. Phillips (2017) Combining gene and stem cell therapy for peripheral nerve tissue engineering. Stem Cells and Development 26(4):231-238
Engineered neural tissue with Schwann cell differentiated human dental pulp stem cells: potential for peripheral nerve repair?
Added 6 January, 2017K. Sanen, W. Martens, M. Georgiou, M. Ameloot, I. Lambrichts & J.B. Phillips (2017) Engineered neural tissue with Schwann cell differentiated human dental pulp stem cells: potential for peripheral nerve repair? Journal of Tissue Engineering and Regenerative Medicine doi: 10.1002/term.2249
An integrated theoretical-experimental approach to accelerate translational tissue engineering
Added 10 November, 2016R.H. Coy, O.R. Evans, J.B. Phillips & R.J. Shipley (2016). An integrated theoretical-experimental approach to accelerate translational tissue engineering. Journal of Tissue Engineering and Regenerative Medicine doi: 10.1002/term.2346
Biomechanical properties of the spinal cord: implications for tissue engineering and clinical translation.
Added 12 September, 2016R.D. Bartlett, D. Choi & J.B. Phillips (2016). Biomechanical properties of the spinal cord: implications for tissue engineering and clinical translation. Regenerative Medicine, (doi:10.2217/rme-2016-0065)
Using Stem Cells to Grow Artificial Tissue for Peripheral Nerve Repair
Added 12 September, 2016K.S. Bhangra, F. Busuttil, J.B. Phillips & A.A. Rahim (2016). Using Stem Cells to Grow Artificial Tissue for Peripheral Nerve Repair. Stem Cells International, ID 7502178
Label-free mapping of microstructural organisation in self-aligning cellular collagen hydrogels using image correlation spectroscopy
Added 21 November, 2015K. Sanen, R. Paesen, S. Luyck, J.B. Phillips, I. Lambrichts, W. Martens & M. Ameloot (2015) Label-free mapping of microstructural organisation in self-aligning cellular collagen hydrogels using image correlation spectroscopy. Acts Biomaterialia doi: 10.1016/j.actbio.2015.10.047
Embryonic and mature astrocytes exert different effects on neuronal growth in rat ventral mesencephalic slice cultures
Added 21 November, 2015Hashemian, C. O'Rourke, J.B. Phillips, I. Strömberg & S. Af Bjerkén (2015) Embryonic and mature astrocytes exert different effects on neuronal growth in rat ventral mesencephalic slice cultures. Springerplus doi: 10.1186/s40064-015-1362-3
Optimising contraction and alignment of cellular collagen hydrogels to achieve reliable and consistent engineered anisotropic tissue.
Added 20 October, 2015O'Rourke, Caitriona; Drake, Rosemary A. L.; Cameron, Grant W. W.; Loughlin, A. Jane and Phillips, James B. (2015). Optimising contraction and alignment of cellular collagen hydrogels to achieve reliable and consistent engineered anisotropic tissue. Journal of Biomaterials Applications (Early view).
Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve.
Added 11 November, 2014Melanie Georgiou, Jon P. Golding, Alison J. Loughlin, Paul J. Kingham and James B. Phillips (2015). Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve. Biomaterials, 37 pp. 242–251.
A three-dimensional collagen construct to model lipopolysaccharide-induced activation of BV2 microglia
Added 7 August, 2014 Haw, Randy Tatt; Tong, Chih Kong; Yew, Andrew; Lee, Han Chung; Phillips, James B.
Monitoring neuron and astrocyte interactions with a 3D cell culture system
Added 6 August, 2014 Phillips, James B.
Building stable anisotropic tissues using cellular collagen gels
Added 11 February, 2014 Phillips, James B.
Human dental pulp stem cells can differentiate into Schwann cells and promote and guide neurite outgrowth in an aligned tissue-engineered collagen construct in vitro
Added 23 December, 2013 Martens, Wendy
Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro
Added 11 December, 2013 Gromnicova, Radka
A 3D in vitro model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury
Added 25 October, 2013 East, Emma
Targeting tumour energy metabolism potentiates the cytotoxicity of 5-aminolevulinic acid photodynamic therapy
Added 24 July, 2013 Golding, J. P.
Engineered neural tissue for peripheral nerve repair
Added 9 July, 2013 Georgiou, Melanie
Fully protected glycosylated zinc (II) phthalocyanine shows high uptake and photodynamic cytotoxicity in MCF-7 cancer cells
Added 26 July, 2012 Kimani, Stanley
Micro-structured materials and mechanical cues in 3D collagen gels
Added 19 July, 2012 Phillips, James
Inhibition of specific cellular antioxidant pathways increases the sensitivity of neurons to meta-tetrahydroxyphenyl chlorin-mediated photodynamic therapy in a 3D co-culture model
Added 11 July, 2012 Wright, Kathleen E.
Engineering an integrated cellular interface in three-dimensional hydrogel cultures permits monitoring of reciprocal astrocyte and neuronal responses
Added 15 February, 2012 East, Emma
Antioxidant inhibitors potentiate the cytotoxicity of photodynamic therapy
Added 16 November, 2011 Kimani, Stanley G.
An ultrastructural and biochemical analysis of collagen in rat peripheral nerves: the relationship between fibril diameter and mechanical properties
Added 21 October, 2011 Mason, Sarah
Micro-structured materials and mechanical cues in 3D collagen gels
Added 21 January, 2011Phillips, James and Brown, Robert (2010). Micro-structured materials and mechanical cues in 3D collagen gels. In: Haycock, John W. ed. 3D Cell Culture. Methods in Molecular Biology (695). New York: Humana Press (Springer Verlag), pp. 183–196.
Alignment of astrocytes increases neuronal growth in three-dimensional collagen gels and is maintained following plastic compression to form a spinal cord repair conduit
Added 18 August, 2010 East, Emma
The neuroprotective effects of fibronectin mats and fibronectin peptides following spinal cord injury in the rat
Added 28 May, 2010 King, V. R.; Hewazy, D.; Alovskaya, A.; Phillips, J. B.
A versatile 3D culture model facilitates monitoring of astrocytes undergoing reactive gliosis
Added 21 October, 2009 East, Emma
Investigating the mechanical shear-plane between core and sheath elements of peripheral nerves
Added 16 September, 2009 Georgeu, G. A.; Walbeehm, E. T.; Tillett, R.; Afoke, A.; Brown, R. A. and Phillips, J. B.
Host muscle cell infiltration in cell-seeded plastic compressed collagen constructs.
Added 7 September, 2009H. Kayhanian, S. Jones, J.B. Phillips, M. Lewis, R. Brown and V. Mudera (2009) Host muscle cell infiltration in cell-seeded plastic compressed collagen constructs. Journal of Tissue Engineering and Regenerative Medicine, 3, 72-75.
Peripheral neural cell sensitivity to mTHPC-mediated photodynamic therapy in a 3D in vitro model
Added 30 July, 2009 Wright, K. E.
Host muscle cell infiltration in cell-seeded plastic compressed collagen constructs
Added 19 November, 2008 Kayhanian, Hamzeh; Jones, Stephanie; Phillips, James
Tissue engineered cell culture models for nervous system research
Added 20 October, 2008East, Emma and Phillips, James B. (2008). Tissue engineered cell culture models for nervous system research. In: Greco, Giovanni N. ed. Tissue Engineering Research Trends. Nova Science Publishers, Inc, pp. 141–160.
Fibronectin, Collagen, Fibrin – Components of Extracellular Matrix for Nerve Regeneration
Added 26 September, 2007Alovskaya, A; Alekseeva, T; Phillips, JB; King, V and Brown, R (2007). Fibronectin, Collagen, Fibrin - Components of Extracellular Matrix for Nerve Regeneration. In: Ashammakhi, N.; Reis, R. L. and Chiellini, E. eds. Topics in tissue engineering, Volume 3. Biomaterials and Tissue Engineering Group.