James Phillips



Publications

Some of our recent publications are listed below. To find more please visit UCL IRIS

 

Latest Papers

In silico model for automated calculation of functional metrics in animal models of peripheral nerve injury repair

Added 11 October, 2024

S Laranjeira, O Guillemot-Legris, G Girmahun, V Roberton, JB Phillips, RJ Shipley (2024) In silico model for automated calculation of functional metrics in animal models of peripheral nerve injury repair.
Computers in Biology and Medicine 181, 109036 https://doi.org/10.1016/j.compbiomed.2024.109036

Formation of vascular-like structures using a chemotaxis-driven multiphase model

Added 11 October, 2024

G Al-Badri, JB Phillips, RJ. Shipley & NC Ovenden (2024) Formation of vascular-like structures using a chemotaxis-driven multiphase model. Mathematical Biosciences 372, 109183 https://doi.org/10.1016/j.mbs.2024.109183

Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing

Added 3 March, 2024

RP Trueman, O Guillemot-Legris, HT Lancashire, AS Mehta, J Tropp, RE Daso, J Rivnay, AB Tabor, JB Phillips & BC Schroeder (2024). Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing. Advanced Engineering Materials, e2301488. 10.1002/adem.202301488.

Electrospun polyvinylidene fluoride with novel facile synthesized functionalized boron nitride quantum dots for neural applications

Added 3 March, 2024

B Ekram, RP Trueman, JB Phillips, H Ros, BM Abd El-Hady, D El-Gendy (2024) Electrospun polyvinylidene fluoride with novel facile synthesized functionalized boron nitride quantum dots for neural applications. Polymer Engineering and Science 10.1002/pen.26632.

Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair

Added 12 October, 2023

HN Gregory, O Guillemot-Legris, D Crouch, G Williams & JB Phillips (2023) Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair. Regenerative Medicine https://doi.org/10.2217/rme-2023-0151

Development of ibuprofen-loaded electrospun materials suitable for surgical implantation in peripheral nerve injury

Added 12 October, 2023

K Dziemidowicz, SC Kellaway, O Guillemot-Legris, O Matar, R Pereira Trindade, VH Roberton, MLD Rayner, GR Williams & JB Phillips (2023) Development of ibuprofen-loaded electrospun materials suitable for surgical implantation in peripheral nerve injury. Biomaterials Advances 154, 213623, https://doi.org/10.1016/j.bioadv.2023.213623

Mathematical modelling with Bayesian inference to quantitatively characterize therapeutic cell behaviour in nerve tissue engineering

Added 12 October, 2023

M Berg, D Eleftheriadou, JB Phillips & RJ Shipley (2023) Mathematical modelling with Bayesian inference to quantitatively characterize therapeutic cell behaviour in nerve tissue engineering. Journal of the Royal Society Interface, 20 (206), 20230258.  10.1098/rsif.2023.0258.

Local Administration of Minocycline Improves Nerve Regeneration in Two Rat Nerve Injury Models

Added 30 July, 2023

O Guillemot-Legris, G Girmahun, RJ Shipley & JB Phillips (2023). Local Administration of Minocycline Improves Nerve Regeneration in Two Rat Nerve Injury Models. Int J Mol Sci 24, 12085

Serum neurofilament light chain measurements following nerve trauma

Added 30 July, 2023

M Wilcox, MLD Rayner, O Guillemot-Legris, I Platt, H Brown, T Quick & JB Phillips (2023). Serum neurofilament light chain measurements following nerve trauma. J Peripher Nerv Syst. https://doi.org/10.1111/jns.12576

Improving the biological interfacing capability of diketopyrrolopyrrole polymers via p-type doping

Added 30 July, 2023

RP Trueman, PG Finn, MM Westwood, A Dey, R Palgrave, A Tabor, JB Phillips & BC Schroeder (2023). Improving the biological interfacing capability of diketopyrrolopyrrole polymers via p-type doping. J Mater Chem C Mater 11, 6943-6950

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

Added 28 May, 2023

G Gong, B Bilanges, B Allsop, GR Masson, V Roberton, T Askwith, S Oxenford, RR Madsen, SE Conduit, D Bellini, M Fitzek, M Collier, O Najam, Z He, B Wahab, SH McLaughlin, AWE Chan, I Feierberg, A Madin, D Morelli, A Bhamra, V Vinciauskaite, KE Anderson, S Surinova, N Pinotsis, E Lopez-Guadamillas, M Wilcox, A Hooper, C Patel, MA Whitehead, TD Bunney, LR Stephens, PT Hawkins, M Katan, DM Yellon, SM Davidson, DM Smith, JB Phillips, R Angell, RL Williams & B Vanhaesebroeck (2023). A small-molecule PI3Kα activator for cardioprotection and neuroregeneration. Nature https://doi.org/10.1038/s41586-023-05972-2

Exploring the Effect of Vitamins B1, B6 and B12 on Neurite Regeneration using a 3D Co-Culture Model of Neurodegeneration

Added 19 May, 2023

PO Smith, RP Trueman, R Powell, H Gregory, JB Phillips, P Bohnhorst & MLD Rayner (2023). Exploring the Effect of Vitamins B1, B6 and B12 on Neurite Regeneration using a 3D Co-Culture Model of Neurodegeneration. International Journal of Physical Medicine & Rehabilitation 11, 1000667

Culture Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-Centre Study

Added 18 March, 2023

Z Huang, R Powell, S Kankowski, JB Phillips & K Haastert-Talini (2023). Culture Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-Centre Study. International Journal of Molecular Sciences 24(6), 5366. https://doi.org/10.3390/ijms24065366

Perspectives on optimizing local delivery of drugs to peripheral nerves using mathematical models

Added 18 March, 2023

S Laranjeira, VH Roberton, JB Phillips, &RJ Shipley (2023). Perspectives on optimizing local delivery of drugs to peripheral nerves using mathematical models. WIREs Mechanisms of Disease,  15( 2), e1593. https://doi.org/10.1002/wsbm.1593

Local delivery of tacrolimus using electrospun poly-ε-caprolactone nanofibres suppresses the T-cell response to peripheral nerve allografts

Added 23 December, 2022

VH Roberton, HN Gregory, U Angkawinitwong, O Mokrane, AS Boyd, RJ Shipley, GR Williams & JB Phillips (2022). Local delivery of tacrolimus using electrospun poly-ε-caprolactone nanofibres suppresses the T-cell response to peripheral nerve allografts. Journal of Neural Engineering https://doi.org/10.1088/1741-2552/acad2a

Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo

Added 23 December, 2022

MLD Rayner, SC Kellaway, I Kingston, O Guillemot-Legris, H Gregory, J Healy & JB Phillips (2022). Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo. Cells 12, 42 https://doi.org/10.3390/cells12010042

Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves

Added 10 December, 2022

SC Kellaway, V Roberton, JN Jones, R Loczenski, JB Phillips, LJ White (2022). Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2022.12.003

Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer’s disease

Added 19 November, 2022

X Li, T Li, P Zhang, X Li, L Lu, Y Sun, B Zhang, S Allen, L White, J Phillips, Z Zhu, H Yao, J Xu (2022). Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease. European Journal of Medicinal Chemistry 244, 114841

Considerations for the use of biomaterials to support cell therapy in neurodegenerative disease

Added 19 November, 2022

VH Roberton & JB Phillips (2022). Considerations for the use of biomaterials to support cell therapy in neurodegenerative disease. International Review of Neurobiology https://doi.org/10.1016/bs.irn.2022.09.009

A combined experimental and computational framework to evaluate the behavior of therapeutic cells for peripheral nerve regeneration

Added 2 May, 2022

D Eleftheriadou, M Berg, JB Phillips & RJ Shipley (2022). A combined experimental and computational framework to evaluate the behavior of therapeutic cells for peripheral nerve regeneration. Biotechnology & Bioengineering https://doi.org/10.1002/bit.28105

Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer’s disease

Added 25 March, 2022

Y Liu, G Uras, I Onuwaje, W Li, H Yao, S Xu, X Li, X Li, J Phillips, S Allen, Q Gong, H Zhang, Z Zhu, J Liu & J Xu (2022). Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 235, 114305

In silico framework to inform the design of repair constructs for peripheral nerve injury repair

Added 20 March, 2022

S Laranjeira, G Pellegrino, KS Bhangra, JB Phillips & RJ Shipley (2022). In silico framework to inform the design of repair constructs for peripheral nerve injury repair. J R Soc Interface, 19, 20210824

An alginate-based encapsulation system for delivery of therapeutic cells to the CNS

Added 1 February, 2022

D. Eleftheriadou, R.E. Evans, E. Atkinson, A. Abdalla, F.K.H. Gavins, A.S. Boyd, G.R. Williams, J.C. Knowles, V.H. Roberton & J.B. Phillips (2022). An alginate-based encapsulation system for delivery of therapeutic cells to the CNS. RSC Adv. 12, 4005-4015

A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering

Added 20 December, 2021

R.P. Trueman, A. S. Ahlawat & J. B. Phillips (2021). A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering. Tissue Engineering Part B: Reviews http://doi.org/10.1089/ten.TEB.2021.0159

Volumetric MRI is a promising outcome measure of muscle reinnervation

Added 17 November, 2021

M Wilcox, L Dos Santos Canas, R Hargunani, T Tidswell, H Brown, M Modat, J Phillips, S Ourselin & T Quick (2021). Volumetric MRI is a promising outcome measure of muscle reinnervation. Sci Rep 11, 22433 (2021). https://doi.org/10.1038/s41598-021-01342-y




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