Publications
Some of our recent publications are listed below. To find more please visit UCL IRIS
Latest Papers
Culture Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-Centre Study
Added 18 March, 2023
Z Huang, R Powell, S Kankowski, JB Phillips & K Haastert-Talini (2023). Culture Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-Centre Study. International Journal of Molecular Sciences 24(6), 5366. https://doi.org/10.3390/ijms24065366
Perspectives on optimizing local delivery of drugs to peripheral nerves using mathematical models
Added 18 March, 2023
S Laranjeira, VH Roberton, JB Phillips, &RJ Shipley (2023). Perspectives on optimizing local delivery of drugs to peripheral nerves using mathematical models. WIREs Mechanisms of Disease, 15( 2), e1593. https://doi.org/10.1002/wsbm.1593
Local delivery of tacrolimus using electrospun poly-ε-caprolactone nanofibres suppresses the T-cell response to peripheral nerve allografts
Added 23 December, 2022
VH Roberton, HN Gregory, U Angkawinitwong, O Mokrane, AS Boyd, RJ Shipley, GR Williams & JB Phillips (2022). Local delivery of tacrolimus using electrospun poly-ε-caprolactone nanofibres suppresses the T-cell response to peripheral nerve allografts. Journal of Neural Engineering https://doi.org/10.1088/1741-2552/acad2a
Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo
Added 23 December, 2022
MLD Rayner, SC Kellaway, I Kingston, O Guillemot-Legris, H Gregory, J Healy & JB Phillips (2022). Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo. Cells 12, 42 https://doi.org/10.3390/cells12010042
Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves
Added 10 December, 2022
SC Kellaway, V Roberton, JN Jones, R Loczenski, JB Phillips, LJ White (2022). Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2022.12.003
Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer’s disease
Added 19 November, 2022
X Li, T Li, P Zhang, X Li, L Lu, Y Sun, B Zhang, S Allen, L White, J Phillips, Z Zhu, H Yao, J Xu (2022). Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease. European Journal of Medicinal Chemistry 244, 114841
Considerations for the use of biomaterials to support cell therapy in neurodegenerative disease
Added 19 November, 2022
VH Roberton & JB Phillips (2022). Considerations for the use of biomaterials to support cell therapy in neurodegenerative disease. International Review of Neurobiology https://doi.org/10.1016/bs.irn.2022.09.009
A combined experimental and computational framework to evaluate the behavior of therapeutic cells for peripheral nerve regeneration
Added 2 May, 2022
D Eleftheriadou, M Berg, JB Phillips & RJ Shipley (2022). A combined experimental and computational framework to evaluate the behavior of therapeutic cells for peripheral nerve regeneration. Biotechnology & Bioengineering https://doi.org/10.1002/bit.28105
Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer’s disease
Added 25 March, 2022
Y Liu, G Uras, I Onuwaje, W Li, H Yao, S Xu, X Li, X Li, J Phillips, S Allen, Q Gong, H Zhang, Z Zhu, J Liu & J Xu (2022). Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 235, 114305
In silico framework to inform the design of repair constructs for peripheral nerve injury repair
Added 20 March, 2022
S Laranjeira, G Pellegrino, KS Bhangra, JB Phillips & RJ Shipley (2022). In silico framework to inform the design of repair constructs for peripheral nerve injury repair. J R Soc Interface, 19, 20210824
An alginate-based encapsulation system for delivery of therapeutic cells to the CNS
Added 1 February, 2022
D. Eleftheriadou, R.E. Evans, E. Atkinson, A. Abdalla, F.K.H. Gavins, A.S. Boyd, G.R. Williams, J.C. Knowles, V.H. Roberton & J.B. Phillips (2022). An alginate-based encapsulation system for delivery of therapeutic cells to the CNS. RSC Adv. 12, 4005-4015
A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering
Added 20 December, 2021
R.P. Trueman, A. S. Ahlawat & J. B. Phillips (2021). A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering. Tissue Engineering Part B: Reviews http://doi.org/10.1089/ten.TEB.2021.0159
Volumetric MRI is a promising outcome measure of muscle reinnervation
Added 17 November, 2021
M Wilcox, L Dos Santos Canas, R Hargunani, T Tidswell, H Brown, M Modat, J Phillips, S Ourselin & T Quick (2021). Volumetric MRI is a promising outcome measure of muscle reinnervation. Sci Rep 11, 22433 (2021). https://doi.org/10.1038/s41598-021-01342-y
Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model
Added 15 September, 2021
M.L.D. Rayner, A.G.E. Day, K.S. Bhangra, J. Sinden & J.B. Phillips (2021). Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2021.08.030
Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries
Added 1 September, 2021
M.L.D. Rayner, J. Healy & J.B. Phillips (2021). Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries. Biomolecules 2021, 11, 1301
‘EngNT’ — Engineering live neural tissue for nerve replacement
Added 24 July, 2021
J.B. Phillips (2021) ‘EngNT’ — Engineering live neural tissue for nerve replacement. Emerging Topics in Life Sciences ETLS20210085
Modelling-informed cell-seeded nerve repair construct designs for treating peripheral nerve injuries
Added 24 July, 2021
R. Coy, M. Berg, J.B. Phillips & R.J. Shipley (2021) Modelling-informed cell-seeded nerve repair construct designs for treating peripheral nerve injuries. PLoS Computational Biology 17, e1009142
Natural biomaterials as instructive engineered microenvironments that direct cellular function in peripheral nerve tissue engineering
Added 8 June, 2021
R. Powell, D. Eleftheriadou, S. Kellaway & J.B. Phillips (2021) Natural biomaterials as instructive engineered microenvironments that direct cellular function in peripheral nerve tissue engineering. Front. Bioeng. Biotechnol. 9:674473
Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regeneration
Added 8 June, 2021
P. Muangsanit, V. Roberton, E. Costa & J.B. Phillips (2021) Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regeneration. Acta Biomaterialia 126, 224-237
Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers?
Added 8 June, 2021
H. Gregory & J.B. Phillips (2021) Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers? Neurochemistry International 143, 104953
Engineered Tissues Made from Human iPSC-Derived Schwann Cells for Investigating Peripheral Nerve Regeneration In Vitro
Added 15 April, 2021
R. Powell & J.B. Phillips (2021) Engineered Tissues Made from Human iPSC-Derived Schwann Cells for Investigating Peripheral Nerve Regeneration In Vitro. In: Stock P., Christ B. (eds) In Vitro Models for Stem Cell Therapy. Methods in Molecular Biology, vol 2269. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1225-5_17
The molecular profile of nerve repair: humans mirror rodents
Added 30 December, 2020
Wilcox MB, Jessen KR, Quick TJ & Phillips JB (2020). The molecular profile of nerve repair: humans mirror rodents. Neural Regeneration Research, 16, 1440-1441
Strategies for Peripheral Nerve Repair
Added 30 December, 2020
Wilcox M, Gregory H, Powell R, Quick TJ & Phillips JB (2020). Strategies for Peripheral Nerve Repair. Current Tissue Microenvironment Reports 1, 49-59
Three-dimensional culture systems in central nervous system research
Added 30 December, 2020
Onuwaje I & Phillips JB (2020). Three-dimensional culture systems in central nervous system research. Handbook of Innovations in Central Nervous System Regenerative Medicine, 571-601
A Tenon’s capsule/bulbar conjunctiva interface biomimetic to model fibrosis and local drug delivery
Added 30 December, 2020
Kozdon, K, Caridi B, Duru I, Ezra DG, Phillips JB & Bailly M (2020). A Tenon's capsule/bulbar conjunctiva interface biomimetic to model fibrosis and local drug delivery. PLoS ONE, 15(11): e0241569