James Phillips



Publications

Some of our recent publications are listed below. To find more please visit UCL IRIS

 

Latest Papers

Culture Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-Centre Study

Added 18 March, 2023

Z Huang, R Powell, S Kankowski, JB Phillips & K Haastert-Talini (2023). Culture Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-Centre Study. International Journal of Molecular Sciences 24(6), 5366. https://doi.org/10.3390/ijms24065366

Perspectives on optimizing local delivery of drugs to peripheral nerves using mathematical models

Added 18 March, 2023

S Laranjeira, VH Roberton, JB Phillips, &RJ Shipley (2023). Perspectives on optimizing local delivery of drugs to peripheral nerves using mathematical models. WIREs Mechanisms of Disease,  15( 2), e1593. https://doi.org/10.1002/wsbm.1593

Local delivery of tacrolimus using electrospun poly-ε-caprolactone nanofibres suppresses the T-cell response to peripheral nerve allografts

Added 23 December, 2022

VH Roberton, HN Gregory, U Angkawinitwong, O Mokrane, AS Boyd, RJ Shipley, GR Williams & JB Phillips (2022). Local delivery of tacrolimus using electrospun poly-ε-caprolactone nanofibres suppresses the T-cell response to peripheral nerve allografts. Journal of Neural Engineering https://doi.org/10.1088/1741-2552/acad2a

Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo

Added 23 December, 2022

MLD Rayner, SC Kellaway, I Kingston, O Guillemot-Legris, H Gregory, J Healy & JB Phillips (2022). Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo. Cells 12, 42 https://doi.org/10.3390/cells12010042

Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves

Added 10 December, 2022

SC Kellaway, V Roberton, JN Jones, R Loczenski, JB Phillips, LJ White (2022). Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2022.12.003

Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer’s disease

Added 19 November, 2022

X Li, T Li, P Zhang, X Li, L Lu, Y Sun, B Zhang, S Allen, L White, J Phillips, Z Zhu, H Yao, J Xu (2022). Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease. European Journal of Medicinal Chemistry 244, 114841

Considerations for the use of biomaterials to support cell therapy in neurodegenerative disease

Added 19 November, 2022

VH Roberton & JB Phillips (2022). Considerations for the use of biomaterials to support cell therapy in neurodegenerative disease. International Review of Neurobiology https://doi.org/10.1016/bs.irn.2022.09.009

A combined experimental and computational framework to evaluate the behavior of therapeutic cells for peripheral nerve regeneration

Added 2 May, 2022

D Eleftheriadou, M Berg, JB Phillips & RJ Shipley (2022). A combined experimental and computational framework to evaluate the behavior of therapeutic cells for peripheral nerve regeneration. Biotechnology & Bioengineering https://doi.org/10.1002/bit.28105

Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer’s disease

Added 25 March, 2022

Y Liu, G Uras, I Onuwaje, W Li, H Yao, S Xu, X Li, X Li, J Phillips, S Allen, Q Gong, H Zhang, Z Zhu, J Liu & J Xu (2022). Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry, 235, 114305

In silico framework to inform the design of repair constructs for peripheral nerve injury repair

Added 20 March, 2022

S Laranjeira, G Pellegrino, KS Bhangra, JB Phillips & RJ Shipley (2022). In silico framework to inform the design of repair constructs for peripheral nerve injury repair. J R Soc Interface, 19, 20210824

An alginate-based encapsulation system for delivery of therapeutic cells to the CNS

Added 1 February, 2022

D. Eleftheriadou, R.E. Evans, E. Atkinson, A. Abdalla, F.K.H. Gavins, A.S. Boyd, G.R. Williams, J.C. Knowles, V.H. Roberton & J.B. Phillips (2022). An alginate-based encapsulation system for delivery of therapeutic cells to the CNS. RSC Adv. 12, 4005-4015

A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering

Added 20 December, 2021

R.P. Trueman, A. S. Ahlawat & J. B. Phillips (2021). A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering. Tissue Engineering Part B: Reviews http://doi.org/10.1089/ten.TEB.2021.0159

Volumetric MRI is a promising outcome measure of muscle reinnervation

Added 17 November, 2021

M Wilcox, L Dos Santos Canas, R Hargunani, T Tidswell, H Brown, M Modat, J Phillips, S Ourselin & T Quick (2021). Volumetric MRI is a promising outcome measure of muscle reinnervation. Sci Rep 11, 22433 (2021). https://doi.org/10.1038/s41598-021-01342-y

Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model

Added 15 September, 2021

M.L.D. Rayner, A.G.E. Day, K.S. Bhangra, J. Sinden & J.B. Phillips (2021). Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2021.08.030

Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries

Added 1 September, 2021

M.L.D. Rayner, J. Healy & J.B. Phillips (2021). Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries. Biomolecules 2021, 11, 1301

‘EngNT’ — Engineering live neural tissue for nerve replacement

Added 24 July, 2021

J.B. Phillips (2021) ‘EngNT’ — Engineering live neural tissue for nerve replacement. Emerging Topics in Life Sciences ETLS20210085

Modelling-informed cell-seeded nerve repair construct designs for treating peripheral nerve injuries

Added 24 July, 2021

R. Coy, M. Berg, J.B. Phillips & R.J. Shipley (2021) Modelling-informed cell-seeded nerve repair construct designs for treating peripheral nerve injuries. PLoS Computational Biology 17, e1009142

Natural biomaterials as instructive engineered microenvironments that direct cellular function in peripheral nerve tissue engineering

Added 8 June, 2021

R. Powell, D. Eleftheriadou, S. Kellaway & J.B. Phillips (2021) Natural biomaterials as instructive engineered microenvironments that direct cellular function in peripheral nerve tissue engineering. Front. Bioeng. Biotechnol. 9:674473

Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regeneration

Added 8 June, 2021

P. Muangsanit, V. Roberton, E. Costa & J.B. Phillips (2021) Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regeneration. Acta Biomaterialia 126, 224-237

Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers?

Added 8 June, 2021

H. Gregory & J.B. Phillips (2021) Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers? Neurochemistry International 143, 104953

Engineered Tissues Made from Human iPSC-Derived Schwann Cells for Investigating Peripheral Nerve Regeneration In Vitro

Added 15 April, 2021

R. Powell & J.B. Phillips (2021) Engineered Tissues Made from Human iPSC-Derived Schwann Cells for Investigating Peripheral Nerve Regeneration In Vitro. In: Stock P., Christ B. (eds) In Vitro Models for Stem Cell Therapy. Methods in Molecular Biology, vol 2269. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1225-5_17

The molecular profile of nerve repair: humans mirror rodents

Added 30 December, 2020

Wilcox MB, Jessen KR, Quick TJ & Phillips JB (2020). The molecular profile of nerve repair: humans mirror rodents. Neural Regeneration Research, 16, 1440-1441

Strategies for Peripheral Nerve Repair

Added 30 December, 2020

Wilcox M, Gregory H, Powell R, Quick TJ & Phillips JB (2020). Strategies for Peripheral Nerve Repair. Current Tissue Microenvironment Reports 1, 49-59

Three-dimensional culture systems in central nervous system research

Added 30 December, 2020

Onuwaje I & Phillips JB (2020). Three-dimensional culture systems in central nervous system research. Handbook of Innovations in Central Nervous System Regenerative Medicine, 571-601

A Tenon’s capsule/bulbar conjunctiva interface biomimetic to model fibrosis and local drug delivery

Added 30 December, 2020

Kozdon, K, Caridi B, Duru I, Ezra DG, Phillips JB & Bailly M (2020). A Tenon's capsule/bulbar conjunctiva interface biomimetic to model fibrosis and local drug delivery. PLoS ONE, 15(11): e0241569




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