New Paper: Using a 3D culture model to understand the effect of PDT on neurons
New Paper: Using a 3D culture model to understand the effect of PDT on neurons
Our paper “Inhibition of specific cellular antioxidant pathways increases the sensitivity of neurons to meta-tetrahydroxyphenyl chlorin-mediated photodynamic therapy in a 3D co-culture model” reveals new information about how neurons can survive photodynamic therapy (PDT) cancer treatments. By using a co-culture system that maintained neurons and glial cells in a 3D environment we were able to identify […]
Read more »Engineered neural tissue with aligned Schwann cells supports neuronal regeneration in vivo and can be assembled using differentiated adipose-derived stem cells
Georgiou, M. ; Loughlin, J. ; Golding, J. P. ; Kingham, P. J. and Phillips, J. B. (2012). Engineered neural tissue with aligned Schwann cells supports neuronal regeneration in vivo and can be assembled using differentiated adipose-derived stem cell…
Read more »Defining glial cell self-alignment parameters for 3D CNS tissue models
O’Rourke, C. M. ; Loughlin, A. J. ; Drake, R. and Phillips, J. B. (2012). Defining glial cell self-alignment parameters for 3D CNS tissue models. In: Annual meeting of the Tissue and Cell Engineering Society (TCES), 4-6 July 2012, Liverpool, UK.
Read more »Astrocytes expressing GFP in 3D collagen gels provide an effective model for screening the glial response to potential CNS cell therapies
Johns, N. ; East, E. ; Golding, J. P. ; Loughlin, A. J. and Phillips, J. B. (2012). Astrocytes expressing GFP in 3D collagen gels provide an effective model for screening the glial response to potential CNS cell therapies. In: Annual meeting of t…
Read more »Developing a 3D co-culture model to simulate perinatal hypoxic-ischaemic brain injury in preterm infants
Osei, E. T.; Evans, L.; Phillips, J. B. and Loughlin, A. J. (2012). Developing a 3D co-culture model to simulate perinatal hypoxic-ischaemic brain injury in preterm infants. In: Annual meeting of the Tissue and Cell Engineering Society (TCES), 4-…
Read more »Inhibition of specific cellular antioxidant pathways increases the sensitivity of neurons to meta-tetrahydroxyphenyl chlorin-mediated photodynamic therapy in a 3D co-culture model
Wright, Kathleen E. ; MacRobert, Alexander J. and Phillips, James B. (2012). Inhibition of specific cellular antioxidant pathways increases the sensitivity of neurons to meta-tetrahydroxyphenyl chlorin-mediated photodynamic therapy in a 3D co-cultu…
Read more »Wellcome Trust Biomedical Vacation Scholarship
We have been awarded a Wellcome Trust Biomedical Vacation Scholarship to support a student working on the project “Using a 3D culture system to monitor the astrocyte response to potential stem cell therapies for CNS damage”. This will take place in the summer of 2012 and will complement other ongoing project to use our nervous […]
Read more »New Paper: 3D culture system models inhibitory interfaces in the damaged nervous system
Our new Tissue Engineering paper “Engineering an integrated cellular interface in 3-dimensional hydrogel cultures permits monitoring of reciprocal astrocyte and neuronal responses” describes a novel cell culture system that recreates key cellular features of the injured spinal cord. Following CNS trauma, astrocytes become reactive and a microenvironment develops that inhibits neuronal regeneration. Our new model mimics that […]
Read more »Engineering an integrated cellular interface in three-dimensional hydrogel cultures permits monitoring of reciprocal astrocyte and neuronal responses
East, Emma ; Golding, Jon P. and Phillips, James B. (2012). Engineering an integrated cellular interface in three-dimensional hydrogel cultures permits monitoring of reciprocal astrocyte and neuronal responses. Tissue Engineering Part C: Methods,…
Read more »PhD Success
Congratulations to Sarah Mason who successfully passed her PhD viva examination on 21st December. Sarah’s PhD Thesis title is “Examining the relationship between ultrastructural features and tensile properties in joint and non joint regions of peripheral nerve” and her project revealed new information about peripheral nerve biomechanics and anatomy.
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