New project optimising photochemical internalisation to avoid neuronal toxicity
New project optimising photochemical internalisation to avoid neuronal toxicity
Photochemical Internalisation (PCI) is a novel drug delivery technology founded upon Photodynamic Therapy (PDT). In PCI, low dose PDT can selectively rupture endo/lysosomal membranes by light activation of membrane-incorporated photosensitisers, facilitating intracellular drug release. PCI is currently being tested in patients at UCLH with advanced head and neck cancer (HNC) undergoing Bleomycin chemotherapy (more information). […]
Read more »New paper: Using adipose-derived stem cells to build artificial nerve tissue
Published in Biomaterials, the paper describes how stem cells from adipose tissue can be used to assemble engineered neural tissue (EngNT) for peripheral nerve repair. Organising adipose stem cell-derived Schwann cells within collagen hydrogels generated a robust cellular material. The cells adopted an aligned phenotype in the EngNT, increased their production of a range of […]
Read more »Label free optical imaging of engineered neural tissue formation by second harmonic signals from collagen type I
Sanen, K. ; Paesen, R.; Martens, W. ; Lambrichts, I.; Phillips, J. B. and Ameloot, M. (2014). Label free optical imaging of engineered neural tissue formation by second harmonic signals from collagen type I. In: 18th International Microscopy Congr…
Read more »A mathematical framework for nerve regeneration in implantable conduits
Evans, O. R.; Phillips, J. B. and Shipley, R. J. (2014). A mathematical framework for nerve regeneration in implantable conduits. In: 2014 Annual Tissue & Cell Engineering Society Meeting, 2-4 July 2014, Newcastle, U.K., p. 106.
Read more »Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve.
Melanie Georgiou, Jon P. Golding, Alison J. Loughlin, Paul J. Kingham and James B. Phillips (2015). Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve. Biomaterials, 37 pp. 242–251.
Read more »‘Ask an Expert’ interview
James was interviewed by Dr Claire Cox from Axol as part of her ‘Ask an Expert‘ blog series.
Read more »Adapting aligned stabilised hydrogels to facilitate large scale drug screening and neurobiological research.
O’Rourke, Caitriona ; Drake, Rosemary; Loughlin, Jane and Phillips, James (2013). Adapting aligned stabilised hydrogels to facilitate large scale drug screening and neurobiological research. In: Future Investigators Of Regenerative Medicine Sympo…
Read more »Adapting aligned, stabilised 3D tissues for large-scale neurobiological research
O’Rourke, Caitriona ; Drake, Rosemary; Loughlin, Jane and Phillips, James (2014). Adapting aligned, stabilised 3D tissues for large-scale neurobiological research. In: Tissue and Cell Engineering Society Annual Conference 2014, 2-4 July 2014, New…
Read more »A three-dimensional collagen construct to model lipopolysaccharide-induced activation of BV2 microglia
Haw, Randy Tatt; Tong, Chih Kong; Yew, Andrew; Lee, Han Chung; Phillips, James B. and Vidyadaran, Sharmili (2014). A three-dimensional collagen construct to model lipopolysaccharide-induced activation of BV2 microglia. Journal of Neuroinflammation…
Read more »Monitoring neuron and astrocyte interactions with a 3D cell culture system
Phillips, James B. (2014). Monitoring neuron and astrocyte interactions with a 3D cell culture system. In: Murray, Andrew J. ed. Axon Growth and Regeneration: Methods and Regeneration. Methods in Molecular Biology: Methods and Protocols, 116…
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