Label-free mapping of microstructural organisation in self-aligning cellular collagen hydrogels using image correlation spectroscopy

K. Sanen, R. Paesen, S. Luyck, J.B. Phillips, I. Lambrichts, W. Martens & M. Ameloot (2015) Label-free mapping of microstructural organisation in self-aligning cellular collagen hydrogels using image correlation spectroscopy. Acts Biomaterialia doi: 10.1016/j.actbio.2015.10.047

Embryonic and mature astrocytes exert different effects on neuronal growth in rat ventral mesencephalic slice cultures

Hashemian, C. O’Rourke, J.B. Phillips, I. Strömberg & S. Af Bjerkén (2015) Embryonic and mature astrocytes exert different effects on neuronal growth in rat ventral mesencephalic slice cultures. Springerplus doi: 10.1186/s40064-015-1362-3

Optimising contraction and alignment of cellular collagen hydrogels to achieve reliable and consistent engineered anisotropic tissue.

O’Rourke, Caitriona; Drake, Rosemary A. L.; Cameron, Grant W. W.; Loughlin, A. Jane and Phillips, James B. (2015). Optimising contraction and alignment of cellular collagen hydrogels to achieve reliable and consistent engineered anisotropic tissue. Journal of Biomaterials Applications (Early view).

3R’s Prize for Replacement, Reduction and Refinement of animal use in science

MSc Clinical Neuroscience student Charlotte Lee-Reeves was awarded the prize for the most innovative research that supported the 3Rs – Replacement, Reduction and Refinement of animal use in science, at the 16th annual Queen Square Symposium. The event saw over 60 PhD and MSc students from the UCL Institute of Neurology exhibiting posters based on […]

New project optimising photochemical internalisation to avoid neuronal toxicity

Photochemical Internalisation (PCI) is a novel drug delivery technology founded upon Photodynamic Therapy (PDT). In PCI, low dose PDT can selectively rupture endo/lysosomal membranes by light activation of membrane-incorporated photosensitisers, facilitating intracellular drug release. PCI is currently being tested in patients at UCLH with advanced head and neck cancer (HNC) undergoing Bleomycin chemotherapy (more information). […]

New paper: Using adipose-derived stem cells to build artificial nerve tissue

Published in Biomaterials, the paper describes how stem cells from adipose tissue can be used to assemble engineered neural tissue (EngNT) for peripheral nerve repair. Organising adipose stem cell-derived Schwann cells within collagen hydrogels generated a robust cellular material. The cells adopted an aligned phenotype in the EngNT, increased their production of a range of […]

Label free optical imaging of engineered neural tissue formation by second harmonic signals from collagen type I

Sanen, K. ; Paesen, R.; Martens, W. ; Lambrichts, I.; Phillips, J. B. and Ameloot, M. (2014). Label free optical imaging of engineered neural tissue formation by second harmonic signals from collagen type I. In: 18th International Microscopy Congr…

A mathematical framework for nerve regeneration in implantable conduits

Evans, O. R.; Phillips, J. B. and Shipley, R. J. (2014). A mathematical framework for nerve regeneration in implantable conduits. In: 2014 Annual Tissue & Cell Engineering Society Meeting, 2-4 July 2014, Newcastle, U.K., p. 106.

Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve.

Melanie Georgiou, Jon P. Golding, Alison J. Loughlin, Paul J. Kingham and James B. Phillips (2015). Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve. Biomaterials, 37 pp. 242–251.

‘Ask an Expert’ interview

James was interviewed by Dr Claire Cox from Axol as part of her ‘Ask an Expert‘ blog series.