New Paper: 3D culture system models inhibitory interfaces in the damaged nervous system

Our new Tissue Engineering paper “Engineering an integrated cellular interface in 3-dimensional hydrogel cultures permits monitoring of reciprocal astrocyte and neuronal responses” describes a novel cell culture system that recreates key cellular features of the injured spinal cord. Following CNS trauma, astrocytes become reactive and a microenvironment develops that inhibits neuronal regeneration. Our new model mimics that […]

Engineering an integrated cellular interface in three-dimensional hydrogel cultures permits monitoring of reciprocal astrocyte and neuronal responses

East, Emma ; Golding, Jon P. and Phillips, James B. (2012). Engineering an integrated cellular interface in three-dimensional hydrogel cultures permits monitoring of reciprocal astrocyte and neuronal responses. Tissue Engineering Part C: Methods,…

PhD Success

Congratulations to Sarah Mason who successfully passed her PhD viva examination on 21st December. Sarah’s PhD Thesis title is “Examining the relationship between ultrastructural features and tensile properties in joint and non joint regions of peripheral nerve” and her project revealed new information about peripheral nerve biomechanics and anatomy.

Antioxidant inhibitors potentiate the cytotoxicity of photodynamic therapy

Kimani, Stanley G. ; Phillips, James B. ; Bruce, James I. ; MacRobert, Alexander J. and Golding, Jon P. (2012). Antioxidant inhibitors potentiate the cytotoxicity of photodynamic therapy. Photochemistry and Photobiology, 88(1) pp. 175–187.

New research project involving industrial collaboration

The group has started an exciting new project in collaboration with TAP Biosystems to develop advanced CNS tissue models for neuroscience research. The project will run for 3 years from October 2011 and will involve close collaboration between scientists and engineers to develop viable production technology to generate advanced culture systems for research and development. […]

New nerve biomechanical anatomy paper

The paper “An ultrastructural and biochemical analysis of collagen in rat peripheral nerves: the relationship between fibril diameter and mechanical properties” by Sarah Mason and James Phillips has been published this week in the Journal of the Peripheral Nervous System. This research revealed that median nerves at the elbow joint showed a pattern of smaller […]

An ultrastructural and biochemical analysis of collagen in rat peripheral nerves: the relationship between fibril diameter and mechanical properties

Mason, Sarah and Phillips, James (2011). An ultrastructural and biochemical analysis of collagen in rat peripheral nerves: the relationship between fibril diameter and mechanical properties. Journal of the Peripheral Nervous System, 16(3) pp. 261…

Aligned Schwann cells within 3D tissue-like gels provide guidance to regenerating neurites

Georgiou, M. ; East, E. ; Loughlin, J. ; Golding, J. and Phillips, J. (2011). Aligned Schwann cells within 3D tissue-like gels provide guidance to regenerating neurites. In: 10th European Meeting on Glial Cells in Health and Disease, 13-17 Septem…

Monitoring glial cell behaviour and neuron-glial interactions in 3D hydrogel and aggregate culture systems

Phillips, J. and Loughlin, J. (2011). Monitoring glial cell behaviour and neuron-glial interactions in 3D hydrogel and aggregate culture systems. In: 10th European Meeting on Glial Cells in Health and Disease, 13-17 September 2011, Prague, Czech …

Schwann cells in collagen gels survive plastic compression and maintain their alignment: development of a cellular biomaterial for peripheral nerve repair

Georgiou, M. ; East, E. ; Loughlin, J. ; Golding, J.P. and Phillips, J.B. (2010). Schwann cells in collagen gels survive plastic compression and maintain their alignment: development of a cellular biomaterial for peripheral nerve repair. In: Tiss…