Inhibition of specific cellular antioxidant pathways increases the sensitivity of neurons to meta-tetrahydroxyphenyl chlorin-mediated photodynamic therapy in a 3D co-culture model
Inhibition of specific cellular antioxidant pathways increases the sensitivity of neurons to meta-tetrahydroxyphenyl chlorin-mediated photodynamic therapy in a 3D co-culture model
Wright, Kathleen E. ; MacRobert, Alexander J. and Phillips, James B. (2012). Inhibition of specific cellular antioxidant pathways increases the sensitivity of neurons to meta-tetrahydroxyphenyl chlorin-mediated photodynamic therapy in a 3D co-cultu…
Read more »Wellcome Trust Biomedical Vacation Scholarship
We have been awarded a Wellcome Trust Biomedical Vacation Scholarship to support a student working on the project “Using a 3D culture system to monitor the astrocyte response to potential stem cell therapies for CNS damage”. This will take place in the summer of 2012 and will complement other ongoing project to use our nervous […]
Read more »New Paper: 3D culture system models inhibitory interfaces in the damaged nervous system
Our new Tissue Engineering paper “Engineering an integrated cellular interface in 3-dimensional hydrogel cultures permits monitoring of reciprocal astrocyte and neuronal responses” describes a novel cell culture system that recreates key cellular features of the injured spinal cord. Following CNS trauma, astrocytes become reactive and a microenvironment develops that inhibits neuronal regeneration. Our new model mimics that […]
Read more »Engineering an integrated cellular interface in three-dimensional hydrogel cultures permits monitoring of reciprocal astrocyte and neuronal responses
East, Emma ; Golding, Jon P. and Phillips, James B. (2012). Engineering an integrated cellular interface in three-dimensional hydrogel cultures permits monitoring of reciprocal astrocyte and neuronal responses. Tissue Engineering Part C: Methods,…
Read more »PhD Success
Congratulations to Sarah Mason who successfully passed her PhD viva examination on 21st December. Sarah’s PhD Thesis title is “Examining the relationship between ultrastructural features and tensile properties in joint and non joint regions of peripheral nerve” and her project revealed new information about peripheral nerve biomechanics and anatomy.
Read more »Antioxidant inhibitors potentiate the cytotoxicity of photodynamic therapy
Kimani, Stanley G. ; Phillips, James B. ; Bruce, James I. ; MacRobert, Alexander J. and Golding, Jon P. (2012). Antioxidant inhibitors potentiate the cytotoxicity of photodynamic therapy. Photochemistry and Photobiology, 88(1) pp. 175–187.
Read more »New research project involving industrial collaboration
The group has started an exciting new project in collaboration with TAP Biosystems to develop advanced CNS tissue models for neuroscience research. The project will run for 3 years from October 2011 and will involve close collaboration between scientists and engineers to develop viable production technology to generate advanced culture systems for research and development. […]
Read more »New nerve biomechanical anatomy paper
The paper “An ultrastructural and biochemical analysis of collagen in rat peripheral nerves: the relationship between fibril diameter and mechanical properties” by Sarah Mason and James Phillips has been published this week in the Journal of the Peripheral Nervous System. This research revealed that median nerves at the elbow joint showed a pattern of smaller […]
Read more »An ultrastructural and biochemical analysis of collagen in rat peripheral nerves: the relationship between fibril diameter and mechanical properties
Mason, Sarah and Phillips, James (2011). An ultrastructural and biochemical analysis of collagen in rat peripheral nerves: the relationship between fibril diameter and mechanical properties. Journal of the Peripheral Nervous System, 16(3) pp. 261…
Read more »Aligned Schwann cells within 3D tissue-like gels provide guidance to regenerating neurites
Georgiou, M. ; East, E. ; Loughlin, J. ; Golding, J. and Phillips, J. (2011). Aligned Schwann cells within 3D tissue-like gels provide guidance to regenerating neurites. In: 10th European Meeting on Glial Cells in Health and Disease, 13-17 Septem…
Read more »