New international collaboration to study microglia in 3D culture

We are involved in a new project entitled ‘Remodelling microglia in vitro in a 3D collagen construct’ in collaboration with Dr Sharmili Vidyadaran at Universiti Putra Malaysia. The PhD student working on the project in Dr Vidyadaran’s lab is Tong Chih Kong and financial support has been provided by the Research University Grant Scheme, Universiti Putra Malaysia.

Engineered neural tissue with columns of aligned Schwann cell-like cells from differentiated adipose-derived stem cells can support and guide neuronal growth in vitro

Georgiou, Melanie ; Kingham, Paul; Golding, Jon ; Loughlin, Jane and Phillips, James (2012). Engineered neural tissue with columns of aligned Schwann cell-like cells from differentiated adipose-derived stem cells can support and guide neuronal gro…

International Conference on Stem Cell Engineering: Travel Award

Melanie Georgiou received a travel award from the Society for Biological Engineering and the International Society for Stem Cell Research to attend the 3rd International Conference on Stem Cell Engineering in Seattle, US. The theme of the meeting was ‘Designing Cellular Therapies’ and the programme and abstracts are available here.

Fully protected glycosylated zinc (II) phthalocyanine shows high uptake and photodynamic cytotoxicity in MCF-7 cancer cells

Kimani, Stanley ; Shmigol, Tatiana; Hammond, Samantha ; Phillips, James B. ; Bruce, James I. ; MacRobert, Alexander J.; Malakhov, Mikhail V. and Golding, Jon P. (2013). Fully protected glycosylated zinc (II) phthalocyanine shows high uptake and pho…

Micro-structured materials and mechanical cues in 3D collagen gels

Phillips, James and Brown, Robert (2010). Micro-structured materials and mechanical cues in 3D collagen gels. In: Haycock, John W. ed. 3D Cell Culture. Methods in Molecular Biology (695). New York: Humana Press, pp. 183–196.

New Paper: Using a 3D culture model to understand the effect of PDT on neurons

Our paper “Inhibition of specific cellular antioxidant pathways increases the sensitivity of neurons to meta-tetrahydroxyphenyl chlorin-mediated photodynamic therapy in a 3D co-culture model” reveals new information about how neurons can survive photodynamic therapy (PDT) cancer treatments. By using a co-culture system that maintained neurons and glial cells in a 3D environment we were able to identify […]

Engineered neural tissue with aligned Schwann cells supports neuronal regeneration in vivo and can be assembled using differentiated adipose-derived stem cells

Georgiou, M. ; Loughlin, J. ; Golding, J. P. ; Kingham, P. J. and Phillips, J. B. (2012). Engineered neural tissue with aligned Schwann cells supports neuronal regeneration in vivo and can be assembled using differentiated adipose-derived stem cell…

Defining glial cell self-alignment parameters for 3D CNS tissue models

O’Rourke, C. M. ; Loughlin, A. J. ; Drake, R. and Phillips, J. B. (2012). Defining glial cell self-alignment parameters for 3D CNS tissue models. In: Annual meeting of the Tissue and Cell Engineering Society (TCES), 4-6 July 2012, Liverpool, UK.

Astrocytes expressing GFP in 3D collagen gels provide an effective model for screening the glial response to potential CNS cell therapies

Johns, N. ; East, E. ; Golding, J. P. ; Loughlin, A. J. and Phillips, J. B. (2012). Astrocytes expressing GFP in 3D collagen gels provide an effective model for screening the glial response to potential CNS cell therapies. In: Annual meeting of t…

Developing a 3D co-culture model to simulate perinatal hypoxic-ischaemic brain injury in preterm infants

Osei, E. T.; Evans, L.; Phillips, J. B. and Loughlin, A. J. (2012). Developing a 3D co-culture model to simulate perinatal hypoxic-ischaemic brain injury in preterm infants. In: Annual meeting of the Tissue and Cell Engineering Society (TCES), 4-…