Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer’s disease
Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer’s disease
Y Liu, G Uras, I Onuwaje, W Li, H Yao, S Xu, X Li, X Li, J Phillips, S Allen, Q Gong, H Zhang, Z Zhu, J Liu & J Xu (2022). Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry, […]
Read more »In silico framework to inform the design of repair constructs for peripheral nerve injury repair
S Laranjeira, G Pellegrino, KS Bhangra, JB Phillips & RJ Shipley (2022). In silico framework to inform the design of repair constructs for peripheral nerve injury repair. J R Soc Interface, 19, 20210824
Read more »An alginate-based encapsulation system for delivery of therapeutic cells to the CNS
D. Eleftheriadou, R.E. Evans, E. Atkinson, A. Abdalla, F.K.H. Gavins, A.S. Boyd, G.R. Williams, J.C. Knowles, V.H. Roberton & J.B. Phillips (2022). An alginate-based encapsulation system for delivery of therapeutic cells to the CNS. RSC Adv. 12, 4005-4015
Read more »Emily Atkinson
Project: Hydrogels for combined delivery of growth factor mimetics and small molecules in the treatment of central nervous system damage. Emily is a Transformative Pharmaceutical Technologies CDT student in the 2020 cohort. Her research focuses on synthesising peptide mimetics and small molecules for local delivery to the brain within a hydrogel formulation. The controlled-release, combination […]
Read more »Isabel Kingston
Technician and Laboratory Manager Previous roles: 2013-2021 Lab Technician, UCL Biomaterials and Tissue Engineering Department. 2011-2012 Senior Scientific Officer, Cancer Research UK, Developmental Signalling Laboratory. 2007-2011 Postdoctoral Fellow, Cancer Research UK, Macromolecular Structure and Function Laboratory. 2004-2006 JSPS Postdoctoral Fellow, Yokohama CU. Drug Design Laboratory. Qualifications: 2004 PhD ‘Interactions of BspMI with two asymmetric Sequences’ […]
Read more »A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering
R.P. Trueman, A. S. Ahlawat & J. B. Phillips (2021). A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering. Tissue Engineering Part B: Reviews http://doi.org/10.1089/ten.TEB.2021.0159
Read more »Volumetric MRI is a promising outcome measure of muscle reinnervation
M Wilcox, L Dos Santos Canas, R Hargunani, T Tidswell, H Brown, M Modat, J Phillips, S Ourselin & T Quick (2021). Volumetric MRI is a promising outcome measure of muscle reinnervation. Sci Rep 11, 22433 (2021). https://doi.org/10.1038/s41598-021-01342-y
Read more »EngNT demonstrates equivalent performance to autograft in preclinical nerve repair
Important new study provides compelling preclinical evidence to support the effectiveness of Engineered Neural Tissue (EngNT) as a replacement for the nerve autograft. Functional regeneration assessed through histological and electrophysiological outcome measures demonstrated equivalent performance. Furthermore, the living replacement nerve tissue was implanted within a collagen membrane wrap, providing an artificial tissue with similar mechanical […]
Read more »Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model
M.L.D. Rayner, A.G.E. Day, K.S. Bhangra, J. Sinden & J.B. Phillips (2021). Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2021.08.030
Read more »Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries
M.L.D. Rayner, J. Healy & J.B. Phillips (2021). Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries. Biomolecules 2021, 11, 1301
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