EngNT demonstrates equivalent performance to autograft in preclinical nerve repair
EngNT demonstrates equivalent performance to autograft in preclinical nerve repair
Important new study provides compelling preclinical evidence to support the effectiveness of Engineered Neural Tissue (EngNT) as a replacement for the nerve autograft. Functional regeneration assessed through histological and electrophysiological outcome measures demonstrated equivalent performance. Furthermore, the living replacement nerve tissue was implanted within a collagen membrane wrap, providing an artificial tissue with similar mechanical […]
Read more »Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model
M.L.D. Rayner, A.G.E. Day, K.S. Bhangra, J. Sinden & J.B. Phillips (2021). Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2021.08.030
Read more »Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries
M.L.D. Rayner, J. Healy & J.B. Phillips (2021). Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries. Biomolecules 2021, 11, 1301
Read more »‘EngNT’ — Engineering live neural tissue for nerve replacement
J.B. Phillips (2021) ‘EngNT’ — Engineering live neural tissue for nerve replacement. Emerging Topics in Life Sciences ETLS20210085
Read more »Modelling-informed cell-seeded nerve repair construct designs for treating peripheral nerve injuries
R. Coy, M. Berg, J.B. Phillips & R.J. Shipley (2021) Modelling-informed cell-seeded nerve repair construct designs for treating peripheral nerve injuries. PLoS Computational Biology 17, e1009142
Read more »Natural biomaterials as instructive engineered microenvironments that direct cellular function in peripheral nerve tissue engineering
R. Powell, D. Eleftheriadou, S. Kellaway & J.B. Phillips (2021) Natural biomaterials as instructive engineered microenvironments that direct cellular function in peripheral nerve tissue engineering. Front. Bioeng. Biotechnol. 9:674473
Read more »Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regeneration
P. Muangsanit, V. Roberton, E. Costa & J.B. Phillips (2021) Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regeneration. Acta Biomaterialia 126, 224-237
Read more »Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers?
H. Gregory & J.B. Phillips (2021) Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers? Neurochemistry International 143, 104953
Read more »Engineered Tissues Made from Human iPSC-Derived Schwann Cells for Investigating Peripheral Nerve Regeneration In Vitro
R. Powell & J.B. Phillips (2021) Engineered Tissues Made from Human iPSC-Derived Schwann Cells for Investigating Peripheral Nerve Regeneration In Vitro. In: Stock P., Christ B. (eds) In Vitro Models for Stem Cell Therapy. Methods in Molecular Biology, vol 2269. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1225-5_17
Read more »The molecular profile of nerve repair: humans mirror rodents
Wilcox MB, Jessen KR, Quick TJ & Phillips JB (2020). The molecular profile of nerve repair: humans mirror rodents. Neural Regeneration Research, 16, 1440-1441
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