Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer’s disease

Y Liu, G Uras, I Onuwaje, W Li, H Yao, S Xu, X Li, X Li, J Phillips, S Allen, Q Gong, H Zhang, Z Zhu, J Liu & J Xu (2022). Novel inhibitors of AChE and Aβaggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry, […]

In silico framework to inform the design of repair constructs for peripheral nerve injury repair

S Laranjeira, G Pellegrino, KS Bhangra, JB Phillips & RJ Shipley (2022). In silico framework to inform the design of repair constructs for peripheral nerve injury repair. J R Soc Interface, 19, 20210824

An alginate-based encapsulation system for delivery of therapeutic cells to the CNS

D. Eleftheriadou, R.E. Evans, E. Atkinson, A. Abdalla, F.K.H. Gavins, A.S. Boyd, G.R. Williams, J.C. Knowles, V.H. Roberton & J.B. Phillips (2022). An alginate-based encapsulation system for delivery of therapeutic cells to the CNS. RSC Adv. 12, 4005-4015

Emily Atkinson

Project: Hydrogels for combined delivery of growth factor mimetics and small molecules in the treatment of central nervous system damage. Emily is a Transformative Pharmaceutical Technologies CDT student in the 2020 cohort. Her research focuses on synthesising peptide mimetics and small molecules for local delivery to the brain within a hydrogel formulation. The controlled-release, combination […]

Isabel Kingston

Technician and Laboratory Manager Previous roles: 2013-2021 Lab Technician, UCL Biomaterials and Tissue Engineering Department. 2011-2012 Senior Scientific Officer, Cancer Research UK, Developmental Signalling Laboratory. 2007-2011 Postdoctoral Fellow, Cancer Research UK, Macromolecular Structure and Function Laboratory. 2004-2006 JSPS Postdoctoral Fellow, Yokohama CU. Drug Design Laboratory. Qualifications: 2004 PhD ‘Interactions of BspMI with two asymmetric Sequences’ […]

A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering

R.P. Trueman, A. S. Ahlawat & J. B. Phillips (2021). A shock to the (nervous) system: Bioelectricity within peripheral nerve tissue engineering. Tissue Engineering Part B: Reviews http://doi.org/10.1089/ten.TEB.2021.0159

Volumetric MRI is a promising outcome measure of muscle reinnervation

M Wilcox, L Dos Santos Canas, R Hargunani, T Tidswell, H Brown, M Modat, J Phillips, S Ourselin & T Quick (2021). Volumetric MRI is a promising outcome measure of muscle reinnervation. Sci Rep 11, 22433 (2021). https://doi.org/10.1038/s41598-021-01342-y

EngNT demonstrates equivalent performance to autograft in preclinical nerve repair

Important new study provides compelling preclinical evidence to support the effectiveness of Engineered Neural Tissue (EngNT) as a replacement for the nerve autograft. Functional regeneration assessed through histological and electrophysiological outcome measures demonstrated equivalent performance. Furthermore, the living replacement nerve tissue was implanted within a collagen membrane wrap, providing an artificial tissue with similar mechanical […]

Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model

M.L.D. Rayner, A.G.E. Day, K.S. Bhangra, J. Sinden & J.B. Phillips (2021). Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2021.08.030

Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries

M.L.D. Rayner, J. Healy & J.B. Phillips (2021). Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries. Biomolecules 2021, 11, 1301